EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES

A series of novel 2-amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K2CO3) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno[2,3-d]pyrimidines (3a-3j) and thieno[2,3-d]pyrimidin-2(1H)...

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Autores principales:	KHATRI,TASLIMAHEMAD T, SHAH,VIRESH H
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2017
Materias:	Gewald reaction thieno[2,3-d]pyrimidines thieno[2,3-d]pyrimidin-2(1H)-ones antimicrobial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100010
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spelling	oai:scielo:S0717-970720170001000102017-05-05EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINESKHATRI,TASLIMAHEMAD TSHAH,VIRESH H Gewald reaction thieno[2,3-d]pyrimidines thieno[2,3-d]pyrimidin-2(1H)-ones antimicrobial activity A series of novel 2-amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K2CO3) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno[2,3-d]pyrimidines (3a-3j) and thieno[2,3-d]pyrimidin-2(1H)-ones(4a-4j) respectively. The reaction rates were faster and yields were higher in the microwave conditions. The structures of the compounds were confirmed with elemental analysis, mass spectral analysis, FTIR, ¹H NMR and 13C NMR techniques. All the synthesized compounds were subjected to antimicrobial activity (MIC) in vitro by broth dilution method and exhibited a moderate antimicrobial activity.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.62 n.1 20172017-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100010en10.4067/S0717-97072017000100010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Gewald reaction thieno[2,3-d]pyrimidines thieno[2,3-d]pyrimidin-2(1H)-ones antimicrobial activity
spellingShingle	Gewald reaction thieno[2,3-d]pyrimidines thieno[2,3-d]pyrimidin-2(1H)-ones antimicrobial activity KHATRI,TASLIMAHEMAD T SHAH,VIRESH H EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES
description	A series of novel 2-amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K2CO3) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno[2,3-d]pyrimidines (3a-3j) and thieno[2,3-d]pyrimidin-2(1H)-ones(4a-4j) respectively. The reaction rates were faster and yields were higher in the microwave conditions. The structures of the compounds were confirmed with elemental analysis, mass spectral analysis, FTIR, ¹H NMR and 13C NMR techniques. All the synthesized compounds were subjected to antimicrobial activity (MIC) in vitro by broth dilution method and exhibited a moderate antimicrobial activity.
author	KHATRI,TASLIMAHEMAD T SHAH,VIRESH H
author_facet	KHATRI,TASLIMAHEMAD T SHAH,VIRESH H
author_sort	KHATRI,TASLIMAHEMAD T
title	EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES
title_short	EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES
title_full	EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES
title_fullStr	EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES
title_full_unstemmed	EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES
title_sort	effective microwave synthesis of bioactive thieno[2,3-d]pyrtmidines
publisher	Sociedad Chilena de Química
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100010
work_keys_str_mv	AT khatritaslimahemadt effectivemicrowavesynthesisofbioactivethieno23dpyrtmidines AT shahvireshh effectivemicrowavesynthesisofbioactivethieno23dpyrtmidines
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EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRTMIDINES

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