EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS
Hydrogels network based on carboxymethylcellulose (CMC) and chitosan (CS), CCI and CC2, have been prepared respectively in the presence or without the crosslinking agents [(N-hydroxysuccinimide (NHS)/N,N'-dicyclohexylcarbodiimide (DCC)] and characterized by FT-IR. The swelling behavior in disti...
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| Autores principales: | , , , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2017
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100014 |
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| Sumario: | Hydrogels network based on carboxymethylcellulose (CMC) and chitosan (CS), CCI and CC2, have been prepared respectively in the presence or without the crosslinking agents [(N-hydroxysuccinimide (NHS)/N,N'-dicyclohexylcarbodiimide (DCC)] and characterized by FT-IR. The swelling behavior in distilled water at 25°C and biological activities have been investigated. CC1 hydrogel revealed higher potential swelling than CC2. Hydrogels showed to possess an important antioxidant activity equal to 66.67% for CC1 and 57.27% for CC2, to scavenge hydroxyl radicals at 2mg/mL. And the values of their reducing power were approximately 53% and 57%. From the hemolytic potential test the obtained materials were hemo-compatible. The anti-inflammatory activity exhibited that hydrogels were able to protect albumin from denaturation. |
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