EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS

Hydrogels network based on carboxymethylcellulose (CMC) and chitosan (CS), CCI and CC2, have been prepared respectively in the presence or without the crosslinking agents [(N-hydroxysuccinimide (NHS)/N,N'-dicyclohexylcarbodiimide (DCC)] and characterized by FT-IR. The swelling behavior in disti...

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Autores principales:	BENGHANEM,SAIDA, CHETOUANI,ASMA, ELKOLLI,MERIEM, BOUNEKHEL,MAHMOUD, BENACHOUR,DJAFAR
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2017
Materias:	Chitosan Carboxymethylcellulose Hydrogels Swelling Biological activities
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100014
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spelling	oai:scielo:S0717-970720170001000142017-05-05EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELSBENGHANEM,SAIDACHETOUANI,ASMAELKOLLI,MERIEMBOUNEKHEL,MAHMOUDBENACHOUR,DJAFAR Chitosan Carboxymethylcellulose Hydrogels Swelling Biological activities Hydrogels network based on carboxymethylcellulose (CMC) and chitosan (CS), CCI and CC2, have been prepared respectively in the presence or without the crosslinking agents [(N-hydroxysuccinimide (NHS)/N,N'-dicyclohexylcarbodiimide (DCC)] and characterized by FT-IR. The swelling behavior in distilled water at 25°C and biological activities have been investigated. CC1 hydrogel revealed higher potential swelling than CC2. Hydrogels showed to possess an important antioxidant activity equal to 66.67% for CC1 and 57.27% for CC2, to scavenge hydroxyl radicals at 2mg/mL. And the values of their reducing power were approximately 53% and 57%. From the hemolytic potential test the obtained materials were hemo-compatible. The anti-inflammatory activity exhibited that hydrogels were able to protect albumin from denaturation.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.62 n.1 20172017-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100014en10.4067/S0717-97072017000100014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Chitosan Carboxymethylcellulose Hydrogels Swelling Biological activities
spellingShingle	Chitosan Carboxymethylcellulose Hydrogels Swelling Biological activities BENGHANEM,SAIDA CHETOUANI,ASMA ELKOLLI,MERIEM BOUNEKHEL,MAHMOUD BENACHOUR,DJAFAR EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS
description	Hydrogels network based on carboxymethylcellulose (CMC) and chitosan (CS), CCI and CC2, have been prepared respectively in the presence or without the crosslinking agents [(N-hydroxysuccinimide (NHS)/N,N'-dicyclohexylcarbodiimide (DCC)] and characterized by FT-IR. The swelling behavior in distilled water at 25°C and biological activities have been investigated. CC1 hydrogel revealed higher potential swelling than CC2. Hydrogels showed to possess an important antioxidant activity equal to 66.67% for CC1 and 57.27% for CC2, to scavenge hydroxyl radicals at 2mg/mL. And the values of their reducing power were approximately 53% and 57%. From the hemolytic potential test the obtained materials were hemo-compatible. The anti-inflammatory activity exhibited that hydrogels were able to protect albumin from denaturation.
author	BENGHANEM,SAIDA CHETOUANI,ASMA ELKOLLI,MERIEM BOUNEKHEL,MAHMOUD BENACHOUR,DJAFAR
author_facet	BENGHANEM,SAIDA CHETOUANI,ASMA ELKOLLI,MERIEM BOUNEKHEL,MAHMOUD BENACHOUR,DJAFAR
author_sort	BENGHANEM,SAIDA
title	EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS
title_short	EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS
title_full	EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS
title_fullStr	EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS
title_full_unstemmed	EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS
title_sort	effects of physical and chemical modification on biological activities of chitosan/ carboxymethylcelluse based hydrogels
publisher	Sociedad Chilena de Química
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000100014
work_keys_str_mv	AT benghanemsaida effectsofphysicalandchemicalmodificationonbiologicalactivitiesofchitosancarboxymethylcellusebasedhydrogels AT chetouaniasma effectsofphysicalandchemicalmodificationonbiologicalactivitiesofchitosancarboxymethylcellusebasedhydrogels AT elkollimeriem effectsofphysicalandchemicalmodificationonbiologicalactivitiesofchitosancarboxymethylcellusebasedhydrogels AT bounekhelmahmoud effectsofphysicalandchemicalmodificationonbiologicalactivitiesofchitosancarboxymethylcellusebasedhydrogels AT benachourdjafar effectsofphysicalandchemicalmodificationonbiologicalactivitiesofchitosancarboxymethylcellusebasedhydrogels
_version_	1714200907216846848

EFFECTS OF PHYSICAL AND CHEMICAL MODIFICATION ON BIOLOGICAL ACTIVITIES OF CHITOSAN/ CARBOXYMETHYLCELLUSE BASED HYDROGELS

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