VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS

A simple and precise stability indicating RP-HPLC method was developed for simultaneous analysis of drug nortriptyline and pregabalin using BDS (250mm x 4.6 mm, 5μ) C18 column at 210 nm of UV detection. Perchloric acid (0.1%) and acetonitrile in the ratio of 55:45 was used as the mobile pha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	POTLURI,HARITHA, BATTULA,SREENIVASA RAO, YETURU,SUNANDAMMA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2017
Materias:	nortriptyline pregabalin HPLC stability indicating validation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000200013
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072017000200013
record_format	dspace
spelling	oai:scielo:S0717-970720170002000132017-06-30VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONSPOTLURI,HARITHABATTULA,SREENIVASA RAOYETURU,SUNANDAMMA nortriptyline pregabalin HPLC stability indicating validation A simple and precise stability indicating RP-HPLC method was developed for simultaneous analysis of drug nortriptyline and pregabalin using BDS (250mm x 4.6 mm, 5μ) C18 column at 210 nm of UV detection. Perchloric acid (0.1%) and acetonitrile in the ratio of 55:45 was used as the mobile phase with a flow rate of 1.0 ml/min and linearity response was established over the concentration range of 5-30 μg/ml for nortriptyline and 37.5-225 μg/ml for pregabalin. The active pharmaceutical ingredients recovered for nortriptyline and pregabalin are in the range of 100.60-101.65% and 100.59-101.74% respectively. The method was validated and was found to be stability indicating and can be successfully utilized for the quantitative analysis of pharmaceutical tablet dosage formulations containing nortriptyline and pregabalin.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.62 n.2 20172017-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000200013en10.4067/S0717-97072017000200013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	nortriptyline pregabalin HPLC stability indicating validation
spellingShingle	nortriptyline pregabalin HPLC stability indicating validation POTLURI,HARITHA BATTULA,SREENIVASA RAO YETURU,SUNANDAMMA VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS
description	A simple and precise stability indicating RP-HPLC method was developed for simultaneous analysis of drug nortriptyline and pregabalin using BDS (250mm x 4.6 mm, 5μ) C18 column at 210 nm of UV detection. Perchloric acid (0.1%) and acetonitrile in the ratio of 55:45 was used as the mobile phase with a flow rate of 1.0 ml/min and linearity response was established over the concentration range of 5-30 μg/ml for nortriptyline and 37.5-225 μg/ml for pregabalin. The active pharmaceutical ingredients recovered for nortriptyline and pregabalin are in the range of 100.60-101.65% and 100.59-101.74% respectively. The method was validated and was found to be stability indicating and can be successfully utilized for the quantitative analysis of pharmaceutical tablet dosage formulations containing nortriptyline and pregabalin.
author	POTLURI,HARITHA BATTULA,SREENIVASA RAO YETURU,SUNANDAMMA
author_facet	POTLURI,HARITHA BATTULA,SREENIVASA RAO YETURU,SUNANDAMMA
author_sort	POTLURI,HARITHA
title	VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS
title_short	VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS
title_full	VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS
title_fullStr	VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS
title_full_unstemmed	VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS
title_sort	validated stability indicating rp-hplc method for simultaneous determination of nortriptyline and pregabalin in bulk and combined dosage formulations
publisher	Sociedad Chilena de Química
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000200013
work_keys_str_mv	AT potluriharitha validatedstabilityindicatingrphplcmethodforsimultaneousdeterminationofnortriptylineandpregabalininbulkandcombineddosageformulations AT battulasreenivasarao validatedstabilityindicatingrphplcmethodforsimultaneousdeterminationofnortriptylineandpregabalininbulkandcombineddosageformulations AT yeturusunandamma validatedstabilityindicatingrphplcmethodforsimultaneousdeterminationofnortriptylineandpregabalininbulkandcombineddosageformulations
_version_	1714200911089238016

VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONS

Ejemplares similares