CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS

ABSTRACT Enantioseparation of nine extensively used chiral pharmaceutical substances from different pharmacological classes and with different structural characteristics has been investigated by capillary zone electrophoresis using Captisol® (sulfobuthylether-β-cyclodextrin sodium salt) as...

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Autores principales:	BUDAU,MONICA, HANCU,GABRIEL, SZABÓ,ZOLTÁN ISTVÁN, KELEMEN,HAJNAL, RUSU,AURA, MUNTEAN,DANIELA LUCIA, CARJE,ANCA GABRIELA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2017
Materias:	chiral separation Captisol® capillary electrophoresis cyclodextrines pharmaceutical analysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000303566
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spelling	oai:scielo:S0717-970720170003035662017-09-08CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGSBUDAU,MONICAHANCU,GABRIELSZABÓ,ZOLTÁN ISTVÁNKELEMEN,HAJNALRUSU,AURAMUNTEAN,DANIELA LUCIACARJE,ANCA GABRIELA chiral separation Captisol® capillary electrophoresis cyclodextrines pharmaceutical analysis ABSTRACT Enantioseparation of nine extensively used chiral pharmaceutical substances from different pharmacological classes and with different structural characteristics has been investigated by capillary zone electrophoresis using Captisol® (sulfobuthylether-β-cyclodextrin sodium salt) as chiral selector. The influence on the chiral separation of several parameters including pH and concentration of the background electrolyte, chiral selector concentration, applied voltage, system temperature and injection parameters were studied and optimized in order to obtain increased chiral resolution and shorten analysis time. The results were compared with those obtained with native and derivatized neutral cyclodextrins (β-cyclodextrin and hydroxypropryl-β-cyclodextrin). All model molecules were resolved using Captisol® as chiral additive and optimized electrophoretic conditions, proving the efficiency of this anionic derivative of β- cyclodextrin as chiral selector in capillary electrophoresis.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.62 n.3 20172017-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000303566en10.4067/s0717-97072017000303566
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	chiral separation Captisol® capillary electrophoresis cyclodextrines pharmaceutical analysis
spellingShingle	chiral separation Captisol® capillary electrophoresis cyclodextrines pharmaceutical analysis BUDAU,MONICA HANCU,GABRIEL SZABÓ,ZOLTÁN ISTVÁN KELEMEN,HAJNAL RUSU,AURA MUNTEAN,DANIELA LUCIA CARJE,ANCA GABRIELA CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS
description	ABSTRACT Enantioseparation of nine extensively used chiral pharmaceutical substances from different pharmacological classes and with different structural characteristics has been investigated by capillary zone electrophoresis using Captisol® (sulfobuthylether-β-cyclodextrin sodium salt) as chiral selector. The influence on the chiral separation of several parameters including pH and concentration of the background electrolyte, chiral selector concentration, applied voltage, system temperature and injection parameters were studied and optimized in order to obtain increased chiral resolution and shorten analysis time. The results were compared with those obtained with native and derivatized neutral cyclodextrins (β-cyclodextrin and hydroxypropryl-β-cyclodextrin). All model molecules were resolved using Captisol® as chiral additive and optimized electrophoretic conditions, proving the efficiency of this anionic derivative of β- cyclodextrin as chiral selector in capillary electrophoresis.
author	BUDAU,MONICA HANCU,GABRIEL SZABÓ,ZOLTÁN ISTVÁN KELEMEN,HAJNAL RUSU,AURA MUNTEAN,DANIELA LUCIA CARJE,ANCA GABRIELA
author_facet	BUDAU,MONICA HANCU,GABRIEL SZABÓ,ZOLTÁN ISTVÁN KELEMEN,HAJNAL RUSU,AURA MUNTEAN,DANIELA LUCIA CARJE,ANCA GABRIELA
author_sort	BUDAU,MONICA
title	CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS
title_short	CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS
title_full	CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS
title_fullStr	CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS
title_full_unstemmed	CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS
title_sort	captisol® as chiral selector in capillary electrophoresis of non-acidic drugs
publisher	Sociedad Chilena de Química
publishDate	2017
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000303566
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CAPTISOL® AS CHIRAL SELECTOR IN CAPILLARY ELECTROPHORESIS OF NON-ACIDIC DRUGS

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