pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (consi...
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| Autores principales: | , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2017
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000403700 |
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| Sumario: | ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period. |
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