pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (consi...
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| Lenguaje: | English |
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Sociedad Chilena de Química
2017
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oai:scielo:S0717-970720170004037002018-04-02pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGELVASCONCELOS,AÉCIO B. P. DESILVA,WAGNER E.BELIAN,MÔNICA F. silica xerogel pH-dependent release ibuprofen ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.62 n.4 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000403700en10.4067/s0717-97072017000403700 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
silica xerogel pH-dependent release ibuprofen |
| spellingShingle |
silica xerogel pH-dependent release ibuprofen VASCONCELOS,AÉCIO B. P. DE SILVA,WAGNER E. BELIAN,MÔNICA F. pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL |
| description |
ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period. |
| author |
VASCONCELOS,AÉCIO B. P. DE SILVA,WAGNER E. BELIAN,MÔNICA F. |
| author_facet |
VASCONCELOS,AÉCIO B. P. DE SILVA,WAGNER E. BELIAN,MÔNICA F. |
| author_sort |
VASCONCELOS,AÉCIO B. P. DE |
| title |
pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL |
| title_short |
pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL |
| title_full |
pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL |
| title_fullStr |
pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL |
| title_full_unstemmed |
pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL |
| title_sort |
ph dependent drug delivery based on silica xerogel |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2017 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000403700 |
| work_keys_str_mv |
AT vasconcelosaeciobpde phdependentdrugdeliverybasedonsilicaxerogel AT silvawagnere phdependentdrugdeliverybasedonsilicaxerogel AT belianmonicaf phdependentdrugdeliverybasedonsilicaxerogel |
| _version_ |
1714200917828435968 |