TRIFLUOROACETIC ACID CATALYZED ONE-POT FOUR-COMPONENT DOMINO REACTION FOR THE SYNTHESIS OF SUBSTITUTED DIHYDRO 2-OXYPYRROLES
ABSTRACT Trifluoroacetic acid was applied as an efficient catalyst for the one-pot four-component synthesis of N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via the domino reaction of amines, formaldehyde and dialkyl acetylenedicarboxylates at ambient temperature in methanol. This methodolo...
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| Autores principales: | , , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2018
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000103799 |
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| Sumario: | ABSTRACT Trifluoroacetic acid was applied as an efficient catalyst for the one-pot four-component synthesis of N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via the domino reaction of amines, formaldehyde and dialkyl acetylenedicarboxylates at ambient temperature in methanol. This methodology includes number of advantages such as: short reaction time, clean work-up, use of inexpensive catalyst, high yields and clean work-up. The work-up of this reaction involves only a filtration and a simple washing step with MeOH, and there is no need for column chromatography. |
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