FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS

ABSTRACT A flow-injection spectrometric method for determination of sodium diclofenac in pharmaceutical formulations was developed on this work. Sodium diclofenac solutions were injected into a stream of deionized water that reacted with potassium permanganate on acid medium producing Mn2+ ions whos...

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Autores principales:	Silva,E. F., Gomes,P. R. B., Fernandes,R. N., Lyra,W. S.
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2018
Materias:	Sodium diclofenac flow-injection analysis injectable solutions tablets
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203941
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spelling	oai:scielo:S0717-970720180002039412018-07-19FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONSSilva,E. F.Gomes,P. R. B.Fernandes,R. N.Lyra,W. S. Sodium diclofenac flow-injection analysis injectable solutions tablets ABSTRACT A flow-injection spectrometric method for determination of sodium diclofenac in pharmaceutical formulations was developed on this work. Sodium diclofenac solutions were injected into a stream of deionized water that reacted with potassium permanganate on acid medium producing Mn2+ ions whose exhibit maximum absorbance at 450 nm. The methodology used optimize experimental parameters was 33 factorial design and response surface. The proposed method obeyed the Beer's Law over the range 25-160 mg L–1, applied in tablets and ampoules samples. Results were compare with the reference method. It was verified at the 95% confidence level, through paired t-test application - there is no statistic difference between them. The detection limit was valued in 2.6 mg L–1, relative standard deviation for 10 consecutive injections was 1.5% (100.0 mg L–1 sodium diclofenac solution) and the sample throughput was 80 samples h–1. Regarding optimization of operational conditions, the FIA spectrometric method presented analytical performance as good as other elaborated flow analyzers. Offers a simple and inexpensive way to this drug indirect determination aiming quality control on pharmaceutical industry's assembly line. However, it can not be used for adulteration screening analysis due to non-selectivity and non-specificity of redox reactions.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.63 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203941en10.4067/s0717-97072018000203941
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Sodium diclofenac flow-injection analysis injectable solutions tablets
spellingShingle	Sodium diclofenac flow-injection analysis injectable solutions tablets Silva,E. F. Gomes,P. R. B. Fernandes,R. N. Lyra,W. S. FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS
description	ABSTRACT A flow-injection spectrometric method for determination of sodium diclofenac in pharmaceutical formulations was developed on this work. Sodium diclofenac solutions were injected into a stream of deionized water that reacted with potassium permanganate on acid medium producing Mn2+ ions whose exhibit maximum absorbance at 450 nm. The methodology used optimize experimental parameters was 33 factorial design and response surface. The proposed method obeyed the Beer's Law over the range 25-160 mg L–1, applied in tablets and ampoules samples. Results were compare with the reference method. It was verified at the 95% confidence level, through paired t-test application - there is no statistic difference between them. The detection limit was valued in 2.6 mg L–1, relative standard deviation for 10 consecutive injections was 1.5% (100.0 mg L–1 sodium diclofenac solution) and the sample throughput was 80 samples h–1. Regarding optimization of operational conditions, the FIA spectrometric method presented analytical performance as good as other elaborated flow analyzers. Offers a simple and inexpensive way to this drug indirect determination aiming quality control on pharmaceutical industry's assembly line. However, it can not be used for adulteration screening analysis due to non-selectivity and non-specificity of redox reactions.
author	Silva,E. F. Gomes,P. R. B. Fernandes,R. N. Lyra,W. S.
author_facet	Silva,E. F. Gomes,P. R. B. Fernandes,R. N. Lyra,W. S.
author_sort	Silva,E. F.
title	FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS
title_short	FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS
title_full	FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS
title_fullStr	FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS
title_full_unstemmed	FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS
title_sort	flow-injection spectrometric determination of sodium diclofenac in pharmaceutical formulations
publisher	Sociedad Chilena de Química
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203941
work_keys_str_mv	AT silvaef flowinjectionspectrometricdeterminationofsodiumdiclofenacinpharmaceuticalformulations AT gomesprb flowinjectionspectrometricdeterminationofsodiumdiclofenacinpharmaceuticalformulations AT fernandesrn flowinjectionspectrometricdeterminationofsodiumdiclofenacinpharmaceuticalformulations AT lyraws flowinjectionspectrometricdeterminationofsodiumdiclofenacinpharmaceuticalformulations
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FLOW-INJECTION SPECTROMETRIC DETERMINATION OF SODIUM DICLOFENAC IN PHARMACEUTICAL FORMULATIONS

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