FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST

ABSTRACT An efficient and greener synthesis of a series of dihydropyrimidone (DHPMs)/ dihydropyrimithione (DHPMTs) derivatives were accomplished via three component one pot condensation between quinoline aldehyde (2-hydroxy-4-formyl quinoline/2-formyl-4-methoxy quinoline), β – ket...

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Autores principales:	Paul,Dhivya, Reddy,Ramanjaneya Gontu, Rajendran,Subramanian Parameswaran
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2018
Materias:	Nickel (II) exchanged zeolite [Ni(II)Y] Biginelli reaction microwave irradiation green condition human pathogens DPPH radical scavenging activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203974
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spelling	oai:scielo:S0717-970720180002039742018-07-19FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYSTPaul,DhivyaReddy,Ramanjaneya GontuRajendran,Subramanian Parameswaran Nickel (II) exchanged zeolite [Ni(II)Y] Biginelli reaction microwave irradiation green condition human pathogens DPPH radical scavenging activity ABSTRACT An efficient and greener synthesis of a series of dihydropyrimidone (DHPMs)/ dihydropyrimithione (DHPMTs) derivatives were accomplished via three component one pot condensation between quinoline aldehyde (2-hydroxy-4-formyl quinoline/2-formyl-4-methoxy quinoline), β – keto ester (ethyl acetoacetate / methyl acetoacetate) and urea/ thiourea using nickel(II) exchanged zeolite [Ni(II)Y] (NiNPs). The NiNPs were characterized by Infrared spectroscopy, Powder X ray diffraction patterns, Electronic microscopy studies- Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). After the course of the reaction, the NiNPs were recovered and reused without any apparent loss of activity. The newly synthesized compounds were screened for antimicrobial activity against two human bacterial pathogens, the Gram-positive Methicillin resistant Staphylococcus aureus (MRSA) and the Gram-negative Pseudomonas aeruginosa (MTCC 201) and a human yeast pathogen, Fluconazole resistant Candida albicans (FRCA). The synthesised compounds were also evaluated for their antioxidant activity and the compounds show significant scavenging activity compared to aspartic acid.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.63 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203974en10.4067/s0717-97072018000203974
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Nickel (II) exchanged zeolite [Ni(II)Y] Biginelli reaction microwave irradiation green condition human pathogens DPPH radical scavenging activity
spellingShingle	Nickel (II) exchanged zeolite [Ni(II)Y] Biginelli reaction microwave irradiation green condition human pathogens DPPH radical scavenging activity Paul,Dhivya Reddy,Ramanjaneya Gontu Rajendran,Subramanian Parameswaran FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST
description	ABSTRACT An efficient and greener synthesis of a series of dihydropyrimidone (DHPMs)/ dihydropyrimithione (DHPMTs) derivatives were accomplished via three component one pot condensation between quinoline aldehyde (2-hydroxy-4-formyl quinoline/2-formyl-4-methoxy quinoline), β – keto ester (ethyl acetoacetate / methyl acetoacetate) and urea/ thiourea using nickel(II) exchanged zeolite [Ni(II)Y] (NiNPs). The NiNPs were characterized by Infrared spectroscopy, Powder X ray diffraction patterns, Electronic microscopy studies- Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). After the course of the reaction, the NiNPs were recovered and reused without any apparent loss of activity. The newly synthesized compounds were screened for antimicrobial activity against two human bacterial pathogens, the Gram-positive Methicillin resistant Staphylococcus aureus (MRSA) and the Gram-negative Pseudomonas aeruginosa (MTCC 201) and a human yeast pathogen, Fluconazole resistant Candida albicans (FRCA). The synthesised compounds were also evaluated for their antioxidant activity and the compounds show significant scavenging activity compared to aspartic acid.
author	Paul,Dhivya Reddy,Ramanjaneya Gontu Rajendran,Subramanian Parameswaran
author_facet	Paul,Dhivya Reddy,Ramanjaneya Gontu Rajendran,Subramanian Parameswaran
author_sort	Paul,Dhivya
title	FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST
title_short	FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST
title_full	FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST
title_fullStr	FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST
title_full_unstemmed	FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST
title_sort	facile ecofriendly one pot synthesis of heterocyclic priviledged medicinal scaffolds via biginelli reaction using retrievable nickel nanoparticles as catalyst
publisher	Sociedad Chilena de Química
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203974
work_keys_str_mv	AT pauldhivya facileecofriendlyonepotsynthesisofheterocyclicpriviledgedmedicinalscaffoldsviabiginellireactionusingretrievablenickelnanoparticlesascatalyst AT reddyramanjaneyagontu facileecofriendlyonepotsynthesisofheterocyclicpriviledgedmedicinalscaffoldsviabiginellireactionusingretrievablenickelnanoparticlesascatalyst AT rajendransubramanianparameswaran facileecofriendlyonepotsynthesisofheterocyclicpriviledgedmedicinalscaffoldsviabiginellireactionusingretrievablenickelnanoparticlesascatalyst
_version_	1714200925586849792

FACILE ECOFRIENDLY ONE POT SYNTHESIS OF HETEROCYCLIC PRIVILEDGED MEDICINAL SCAFFOLDS VIA BIGINELLI REACTION USING RETRIEVABLE NICKEL NANOPARTICLES AS CATALYST

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