DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY

ABSTRACT The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. The most popular oral solid dosage forms are tablets and capsules. Many patients find it difficult to sw...

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Autor principal:	Vishvakarma,Prabhakar
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2018
Materias:	BisoprololFumarate Fast dissolving film HPMC Maltodextrin Solvent casting method 32 factorial The formulations were subjected to disintegration in-vitro drug release test The in vitro disintegration time of the optimized batch F4 was found to be 20 sec The optimized batch was found to be stable for 1 month under specified stability conditions
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203988
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spelling	oai:scielo:S0717-970720180002039882018-07-19DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACYVishvakarma,Prabhakar BisoprololFumarate Fast dissolving film HPMC Maltodextrin Solvent casting method 32 factorial The formulations were subjected to disintegration in-vitro drug release test The in vitro disintegration time of the optimized batch F4 was found to be 20 sec The optimized batch was found to be stable for 1 month under specified stability conditions ABSTRACT The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. The most popular oral solid dosage forms are tablets and capsules. Many patients find it difficult to swallow tablets and hard gelatin capsules particularly pediatric and geriatric patients and do not take their medicines as prescribed. The objective of this research was to prepare fast dissolving oral thin film (FDOTF) containing Montelukast sodium is indicated for the prophylaxis and chronic treatment of asthma to enhance convenience and compliance to the elderly and pediatric patients for better therapeutic efficacy. The present investigation was undertaken with the objective of formulating of the montelukast sodium fast dissolving oral thin films allowing fast reproducible drug dissolution in oral cavity thus bypassing first pass metabolism. The film were prepared by using polymers such as hydroxypropyl methyl cellulose (HPMC) and Maltodextrin, plasticizer such as PEG 400, by a solvent casting method. They were evaluated for physical characteristics such as thickness, uniformity of weight, folding endurance, drug content, surface ph, percentage elongation and tensile strength, drug polymers compatibility by FTIR study, scanning electron microscopy and in vitro drug release. The formulations were subjected to disintegration, in-vitro drug release test. The in vitro disintegration time of the optimized batch F4 was found to be 20 sec. The optimized batch was found to be stable for 1 month under specified stability conditions.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.63 n.2 20182018-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203988en10.4067/s0717-97072018000203988
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	BisoprololFumarate Fast dissolving film HPMC Maltodextrin Solvent casting method 32 factorial The formulations were subjected to disintegration in-vitro drug release test The in vitro disintegration time of the optimized batch F4 was found to be 20 sec The optimized batch was found to be stable for 1 month under specified stability conditions
spellingShingle	BisoprololFumarate Fast dissolving film HPMC Maltodextrin Solvent casting method 32 factorial The formulations were subjected to disintegration in-vitro drug release test The in vitro disintegration time of the optimized batch F4 was found to be 20 sec The optimized batch was found to be stable for 1 month under specified stability conditions Vishvakarma,Prabhakar DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY
description	ABSTRACT The oral route is most popular route for the administration of therapeutic agents because of the low cost of therapy and ease of administration lead to high levels of patient compliance. The most popular oral solid dosage forms are tablets and capsules. Many patients find it difficult to swallow tablets and hard gelatin capsules particularly pediatric and geriatric patients and do not take their medicines as prescribed. The objective of this research was to prepare fast dissolving oral thin film (FDOTF) containing Montelukast sodium is indicated for the prophylaxis and chronic treatment of asthma to enhance convenience and compliance to the elderly and pediatric patients for better therapeutic efficacy. The present investigation was undertaken with the objective of formulating of the montelukast sodium fast dissolving oral thin films allowing fast reproducible drug dissolution in oral cavity thus bypassing first pass metabolism. The film were prepared by using polymers such as hydroxypropyl methyl cellulose (HPMC) and Maltodextrin, plasticizer such as PEG 400, by a solvent casting method. They were evaluated for physical characteristics such as thickness, uniformity of weight, folding endurance, drug content, surface ph, percentage elongation and tensile strength, drug polymers compatibility by FTIR study, scanning electron microscopy and in vitro drug release. The formulations were subjected to disintegration, in-vitro drug release test. The in vitro disintegration time of the optimized batch F4 was found to be 20 sec. The optimized batch was found to be stable for 1 month under specified stability conditions.
author	Vishvakarma,Prabhakar
author_facet	Vishvakarma,Prabhakar
author_sort	Vishvakarma,Prabhakar
title	DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY
title_short	DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY
title_full	DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY
title_fullStr	DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY
title_full_unstemmed	DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY
title_sort	design and development of montelukast sodium fast dissolving films for better therapeutic efficacy
publisher	Sociedad Chilena de Química
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000203988
work_keys_str_mv	AT vishvakarmaprabhakar designanddevelopmentofmontelukastsodiumfastdissolvingfilmsforbettertherapeuticefficacy
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DESIGN AND DEVELOPMENT OF MONTELUKAST SODIUM FAST DISSOLVING FILMS FOR BETTER THERAPEUTIC EFFICACY

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