DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE

ABSTRACT The electrochemical oxidation of hydroxyzine dihydrochloride at carbon paste electrode has been studied in 0.04 M Britton-Robinson buffer pH 6.2 using cyclic and differential pulse voltammetry. The oxidation process has been shown to irreversible and diffusion controlled with adsorption cha...

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Autores principales:	Zayed,Sayed I. M., Al-Talhi,Amal A. H., Thagafi,Asmaa E. Al
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2018
Materias:	Hydroxyzine dihydrochloride differential pulse anoding voltammetry carbon paste electrodes pharmaceutical dosage form human urine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000304064
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spelling	oai:scielo:S0717-970720180003040642018-10-03DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODEZayed,Sayed I. M.Al-Talhi,Amal A. H.Thagafi,Asmaa E. Al Hydroxyzine dihydrochloride differential pulse anoding voltammetry carbon paste electrodes pharmaceutical dosage form human urine ABSTRACT The electrochemical oxidation of hydroxyzine dihydrochloride at carbon paste electrode has been studied in 0.04 M Britton-Robinson buffer pH 6.2 using cyclic and differential pulse voltammetry. The oxidation process has been shown to irreversible and diffusion controlled with adsorption characterstics. Based on these studies, simple, rapid, and sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.45-5.36 μg/ml, with detection and quantification limits of 0.27 and 0.90 μg/ml hydroxyzine dihydrochloride, respectively. The proposed method was successfully used for quantification of hydroxyzine dihydrochloride in Atarax tablets and spiked human urine.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.63 n.3 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000304064en10.4067/s0717-97072018000304064
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hydroxyzine dihydrochloride differential pulse anoding voltammetry carbon paste electrodes pharmaceutical dosage form human urine
spellingShingle	Hydroxyzine dihydrochloride differential pulse anoding voltammetry carbon paste electrodes pharmaceutical dosage form human urine Zayed,Sayed I. M. Al-Talhi,Amal A. H. Thagafi,Asmaa E. Al DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE
description	ABSTRACT The electrochemical oxidation of hydroxyzine dihydrochloride at carbon paste electrode has been studied in 0.04 M Britton-Robinson buffer pH 6.2 using cyclic and differential pulse voltammetry. The oxidation process has been shown to irreversible and diffusion controlled with adsorption characterstics. Based on these studies, simple, rapid, and sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.45-5.36 μg/ml, with detection and quantification limits of 0.27 and 0.90 μg/ml hydroxyzine dihydrochloride, respectively. The proposed method was successfully used for quantification of hydroxyzine dihydrochloride in Atarax tablets and spiked human urine.
author	Zayed,Sayed I. M. Al-Talhi,Amal A. H. Thagafi,Asmaa E. Al
author_facet	Zayed,Sayed I. M. Al-Talhi,Amal A. H. Thagafi,Asmaa E. Al
author_sort	Zayed,Sayed I. M.
title	DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE
title_short	DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE
title_full	DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE
title_fullStr	DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE
title_full_unstemmed	DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE
title_sort	determination of hydroxyzine by differential pulse anodic voltammetry using carbon paste electrode
publisher	Sociedad Chilena de Química
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000304064
work_keys_str_mv	AT zayedsayedim determinationofhydroxyzinebydifferentialpulseanodicvoltammetryusingcarbonpasteelectrode AT altalhiamalah determinationofhydroxyzinebydifferentialpulseanodicvoltammetryusingcarbonpasteelectrode AT thagafiasmaaeal determinationofhydroxyzinebydifferentialpulseanodicvoltammetryusingcarbonpasteelectrode
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DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE

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