STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS

ABSTRACT A stability-indicating LC method was developed and validated for the determination of risperidone in tablets. Quantitation was achieved by LC/DAD at 294 nm over the concentration range of 25.00 μg/mL to 250.00 μg/mL. Mobile phase was a mixture of water: glacial acetic acid...

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Autores principales:	Mennickent,Sigrid, Diego,Marta de, Liser,Bernd, Trujillo,Lina
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2018
Materias:	risperidone stability-indicating method LC tablets stress testing
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000304150
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spelling	oai:scielo:S0717-970720180003041502018-10-03STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETSMennickent,SigridDiego,Marta deLiser,BerndTrujillo,Lina risperidone stability-indicating method LC tablets stress testing ABSTRACT A stability-indicating LC method was developed and validated for the determination of risperidone in tablets. Quantitation was achieved by LC/DAD at 294 nm over the concentration range of 25.00 μg/mL to 250.00 μg/mL. Mobile phase was a mixture of water: glacial acetic acid 0.50 %: triethylamine 0.80 %: acetonitrile (65.00: 0.32: 0.52: 34.16, v/v), using a Purosphere STAR RP-18e 250 × 4.5 mm (5μ) column, and paroxetine as internal standard. The method exhibited an adequate linearity (r = 0.999), selectivity, precision (RSD ≤ 0.847 %) and accuracy (recoveries from 99.55 % to 101.35 %). Risperidone was subjected to the stress conditions of oxidative, acid, base, thermal and photolytic degradation. Risperidone was found no degrade in basic or acid stress conditions, neither in thermal stress exposition (50, 70 and 100 °C) no at visible or UV stress conditions, during the time of the study. Only two degradation products were observed with peroxide oxidation, well resolved from analyte peak, proving the stability-indicating power of the method. The proposed method was found to be suitable for quantitative determination and the stability studies of risperidone in tablets.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.63 n.3 20182018-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000304150en10.4067/s0717-97072018000304150
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	risperidone stability-indicating method LC tablets stress testing
spellingShingle	risperidone stability-indicating method LC tablets stress testing Mennickent,Sigrid Diego,Marta de Liser,Bernd Trujillo,Lina STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS
description	ABSTRACT A stability-indicating LC method was developed and validated for the determination of risperidone in tablets. Quantitation was achieved by LC/DAD at 294 nm over the concentration range of 25.00 μg/mL to 250.00 μg/mL. Mobile phase was a mixture of water: glacial acetic acid 0.50 %: triethylamine 0.80 %: acetonitrile (65.00: 0.32: 0.52: 34.16, v/v), using a Purosphere STAR RP-18e 250 × 4.5 mm (5μ) column, and paroxetine as internal standard. The method exhibited an adequate linearity (r = 0.999), selectivity, precision (RSD ≤ 0.847 %) and accuracy (recoveries from 99.55 % to 101.35 %). Risperidone was subjected to the stress conditions of oxidative, acid, base, thermal and photolytic degradation. Risperidone was found no degrade in basic or acid stress conditions, neither in thermal stress exposition (50, 70 and 100 °C) no at visible or UV stress conditions, during the time of the study. Only two degradation products were observed with peroxide oxidation, well resolved from analyte peak, proving the stability-indicating power of the method. The proposed method was found to be suitable for quantitative determination and the stability studies of risperidone in tablets.
author	Mennickent,Sigrid Diego,Marta de Liser,Bernd Trujillo,Lina
author_facet	Mennickent,Sigrid Diego,Marta de Liser,Bernd Trujillo,Lina
author_sort	Mennickent,Sigrid
title	STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS
title_short	STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS
title_full	STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS
title_fullStr	STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS
title_full_unstemmed	STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS
title_sort	stability indicating hplc method for quantification of risperidone in tablets
publisher	Sociedad Chilena de Química
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000304150
work_keys_str_mv	AT mennickentsigrid stabilityindicatinghplcmethodforquantificationofrisperidoneintablets AT diegomartade stabilityindicatinghplcmethodforquantificationofrisperidoneintablets AT liserbernd stabilityindicatinghplcmethodforquantificationofrisperidoneintablets AT trujillolina stabilityindicatinghplcmethodforquantificationofrisperidoneintablets
_version_	1714200930033860608

STABILITY INDICATING HPLC METHOD FOR QUANTIFICATION OF RISPERIDONE IN TABLETS

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