ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA

ABSTRACT The antibacterial activity of two natural diterpenoids isolated from Azorella compacta together with six semisynthetic derivatives, were evaluated against three bacteria: Staphylococcus aureus, Escherichia coli and Mycobacterium smegmatis. The synthesis of the semisynthetic derivatives 3-5...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Núñez,S., San-Martín,A., Corsini,G.
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2018
Materias:	Azorella compacta Apiaceae diterpenoids antibacterial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000404200
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0717-97072018000404200
record_format	dspace
spelling	oai:scielo:S0717-970720180004042002019-02-07ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTANúñez,S.San-Martín,A.Corsini,G. Azorella compacta Apiaceae diterpenoids antibacterial activity ABSTRACT The antibacterial activity of two natural diterpenoids isolated from Azorella compacta together with six semisynthetic derivatives, were evaluated against three bacteria: Staphylococcus aureus, Escherichia coli and Mycobacterium smegmatis. The synthesis of the semisynthetic derivatives 3-5 and 8 have not been previously reported with the methods described in this research. The structures of all diterpenoids were elucidated by NMR 1H, 13C and IR spectroscopy. The natural diterpenoids, mulinolic ácid (1) and azorellanol (2) did not present antibacterial activity, but the six derivatives: 12-oxo-11,13-α,α-dihydroxymulin-20-oic ácid (3), 11-oxo-12,13-α,α-dihydroxymulin-20-oic ácid (4) 11,12-dioxo-13-α-hydroxymulin-20-oic ácid (5), 7-acetoxymulin-9,12-diene (6), mulin-9,12-dien-7-ol (7) and 7-acetoxy-12,13-dihydroxymulin-9-en (8) were active against three tested bacteria. The antibacterial activity reported for six semisynthetic diterpenoids may not be comparable with positive control ampicillin but demonstrate the possibility of modification of the biological activity of diterpenoids.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.63 n.4 20182018-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000404200en10.4067/S0717-97072018000404200
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Azorella compacta Apiaceae diterpenoids antibacterial activity
spellingShingle	Azorella compacta Apiaceae diterpenoids antibacterial activity Núñez,S. San-Martín,A. Corsini,G. ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
description	ABSTRACT The antibacterial activity of two natural diterpenoids isolated from Azorella compacta together with six semisynthetic derivatives, were evaluated against three bacteria: Staphylococcus aureus, Escherichia coli and Mycobacterium smegmatis. The synthesis of the semisynthetic derivatives 3-5 and 8 have not been previously reported with the methods described in this research. The structures of all diterpenoids were elucidated by NMR 1H, 13C and IR spectroscopy. The natural diterpenoids, mulinolic ácid (1) and azorellanol (2) did not present antibacterial activity, but the six derivatives: 12-oxo-11,13-α,α-dihydroxymulin-20-oic ácid (3), 11-oxo-12,13-α,α-dihydroxymulin-20-oic ácid (4) 11,12-dioxo-13-α-hydroxymulin-20-oic ácid (5), 7-acetoxymulin-9,12-diene (6), mulin-9,12-dien-7-ol (7) and 7-acetoxy-12,13-dihydroxymulin-9-en (8) were active against three tested bacteria. The antibacterial activity reported for six semisynthetic diterpenoids may not be comparable with positive control ampicillin but demonstrate the possibility of modification of the biological activity of diterpenoids.
author	Núñez,S. San-Martín,A. Corsini,G.
author_facet	Núñez,S. San-Martín,A. Corsini,G.
author_sort	Núñez,S.
title	ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
title_short	ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
title_full	ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
title_fullStr	ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
title_full_unstemmed	ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA
title_sort	antimicrobial activities of diterpenoids and semisynthetic derivatives from azorella compacta
publisher	Sociedad Chilena de Química
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072018000404200
work_keys_str_mv	AT nunezs antimicrobialactivitiesofditerpenoidsandsemisyntheticderivativesfromazorellacompacta AT sanmartina antimicrobialactivitiesofditerpenoidsandsemisyntheticderivativesfromazorellacompacta AT corsinig antimicrobialactivitiesofditerpenoidsandsemisyntheticderivativesfromazorellacompacta
_version_	1714200931652861952

ANTIMICROBIAL ACTIVITIES OF DITERPENOIDS AND SEMISYNTHETIC DERIVATIVES FROM AZORELLA COMPACTA

Ejemplares similares