CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS

ABSTRACT A multi-walled carbon nanotube (MWCNT)-ionic liquid (IL) film-modified glassy carbon electrode (GCE) was constructed for the determination of pseudoephedrine (PE) and chlorpheniramine (CP) by differential pulse voltammetry (DPV). The MWCNT-IL film has shown an obvious electrocatalytic activ...

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Autores principales: Pérez-Ortiz,M., Pizarro,P., Álvarez-Lueje,A.
Lenguaje:English
Publicado: Sociedad Chilena de Química 2019
Materias:
Pseudoephedrine
Chlorpheniramine
Carbon nanotubes
Ionic liquids
Modified electrodes
Voltammetry
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000104324
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spelling oai:scielo:S0717-970720190001043242019-04-11CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALSPérez-Ortiz,M.Pizarro,P.Álvarez-Lueje,A. Pseudoephedrine Chlorpheniramine Carbon nanotubes Ionic liquids Modified electrodes Voltammetry ABSTRACT A multi-walled carbon nanotube (MWCNT)-ionic liquid (IL) film-modified glassy carbon electrode (GCE) was constructed for the determination of pseudoephedrine (PE) and chlorpheniramine (CP) by differential pulse voltammetry (DPV). The MWCNT-IL film has shown an obvious electrocatalytic activity towards oxidation of PE and CP, since it increases the electroactive area, facilitates the electron transfer and significantly enhances the oxidation peak current of both. Also a synergistic effect between MWCNT and IL was detected; it improves the conductivity, resulting in a better response, thus the modified electrode presented higher sensitivity. Under the optimum conditions, the oxidation peak currents were linearly proportional to the concentration in the range from 40.3 to 161.3 µg/mL for PE and from 0.39 µg/mL to 27.4 µg/mL for CP. Detection limits were 32.4 µg/mL with 180 s accumulation for PE and 0.11 µg/mL with 240 s accumulation for CP. Finally, the proposed sensitive and simple electrochemical method was successfully applied to PE and CP determination in a pharmaceutical formulation, and recoveries were acceptable.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.64 n.1 20192019-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000104324en10.4067/s0717-97072019000104324
institution Scielo Chile
collection Scielo Chile
language English
topic Pseudoephedrine
Chlorpheniramine
Carbon nanotubes
Ionic liquids
Modified electrodes
Voltammetry
spellingShingle Pseudoephedrine
Chlorpheniramine
Carbon nanotubes
Ionic liquids
Modified electrodes
Voltammetry
Pérez-Ortiz,M.
Pizarro,P.
Álvarez-Lueje,A.
CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS
description ABSTRACT A multi-walled carbon nanotube (MWCNT)-ionic liquid (IL) film-modified glassy carbon electrode (GCE) was constructed for the determination of pseudoephedrine (PE) and chlorpheniramine (CP) by differential pulse voltammetry (DPV). The MWCNT-IL film has shown an obvious electrocatalytic activity towards oxidation of PE and CP, since it increases the electroactive area, facilitates the electron transfer and significantly enhances the oxidation peak current of both. Also a synergistic effect between MWCNT and IL was detected; it improves the conductivity, resulting in a better response, thus the modified electrode presented higher sensitivity. Under the optimum conditions, the oxidation peak currents were linearly proportional to the concentration in the range from 40.3 to 161.3 µg/mL for PE and from 0.39 µg/mL to 27.4 µg/mL for CP. Detection limits were 32.4 µg/mL with 180 s accumulation for PE and 0.11 µg/mL with 240 s accumulation for CP. Finally, the proposed sensitive and simple electrochemical method was successfully applied to PE and CP determination in a pharmaceutical formulation, and recoveries were acceptable.
author Pérez-Ortiz,M.
Pizarro,P.
Álvarez-Lueje,A.
author_facet Pérez-Ortiz,M.
Pizarro,P.
Álvarez-Lueje,A.
author_sort Pérez-Ortiz,M.
title CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS
title_short CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS
title_full CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS
title_fullStr CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS
title_full_unstemmed CARBON NANOTUBES–IONIC LIQUID GEL. CHARACTERIZATION AND APPLICATION TO PSEUDOEPHEDRINE AND CHLORPHENIRAMINE DETERMINATION IN PHARMACEUTICALS
title_sort carbon nanotubes–ionic liquid gel. characterization and application to pseudoephedrine and chlorpheniramine determination in pharmaceuticals
publisher Sociedad Chilena de Química
publishDate 2019
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000104324
work_keys_str_mv AT perezortizm carbonnanotubes8211ionicliquidgelcharacterizationandapplicationtopseudoephedrineandchlorpheniraminedeterminationinpharmaceuticals
AT pizarrop carbonnanotubes8211ionicliquidgelcharacterizationandapplicationtopseudoephedrineandchlorpheniraminedeterminationinpharmaceuticals
AT alvarezluejea carbonnanotubes8211ionicliquidgelcharacterizationandapplicationtopseudoephedrineandchlorpheniraminedeterminationinpharmaceuticals
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