SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES

ABSTRACT Kinetic spectrophotometry methods have levels of accuracy and sensitivity which are comparable to those of other methods and have been used in the quantification of different pharmaceutical analytes in different matrices. This work describes an indirect kinetic spectrophotometric method for...

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Autores principales:	Soto,César A., Saavedra,Renato A., Poza,Cristian A., Contreras,David R., Oyarzún,Diego P., Toral,María I.
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2019
Materias:	Kinetic Spectrophotometric Diphenhydramine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304507
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spelling	oai:scielo:S0717-970720190003045072019-11-06SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLESSoto,César A.Saavedra,Renato A.Poza,Cristian A.Contreras,David R.Oyarzún,Diego P.Toral,María I. Kinetic Spectrophotometric Diphenhydramine ABSTRACT Kinetic spectrophotometry methods have levels of accuracy and sensitivity which are comparable to those of other methods and have been used in the quantification of different pharmaceutical analytes in different matrices. This work describes an indirect kinetic spectrophotometric method for the determination of diphenhydramine by the alkaline oxidation with permanganate in pharmaceutical formulations (injection) and tap water spiked samples. Measurements of changes in absorbance at 610 nm were used as criterion of the reaction progress. The optimization of chemical variables of oxidation reaction was realized using experimental design by multivariate analysis. The optimized values were 20 min of reaction time, KMnO4 1.00x10−3 molL−1, Na2SO4 0.20 molL-1 and NaOH 0.20 molL-1. Under these conditions calibration curves were constructed. The detection limits obtained in pharmaceutical formulations (injection) and tap water spiked samples, were 9.65x10-7 mol L−1 and 1.23x10-6 mol L−1, respectively. The method is simple and does not require expensive instruments or complicated extraction steps of the reaction productinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.64 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304507en10.4067/S0717-97072019000304507
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Kinetic Spectrophotometric Diphenhydramine
spellingShingle	Kinetic Spectrophotometric Diphenhydramine Soto,César A. Saavedra,Renato A. Poza,Cristian A. Contreras,David R. Oyarzún,Diego P. Toral,María I. SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES
description	ABSTRACT Kinetic spectrophotometry methods have levels of accuracy and sensitivity which are comparable to those of other methods and have been used in the quantification of different pharmaceutical analytes in different matrices. This work describes an indirect kinetic spectrophotometric method for the determination of diphenhydramine by the alkaline oxidation with permanganate in pharmaceutical formulations (injection) and tap water spiked samples. Measurements of changes in absorbance at 610 nm were used as criterion of the reaction progress. The optimization of chemical variables of oxidation reaction was realized using experimental design by multivariate analysis. The optimized values were 20 min of reaction time, KMnO4 1.00x10−3 molL−1, Na2SO4 0.20 molL-1 and NaOH 0.20 molL-1. Under these conditions calibration curves were constructed. The detection limits obtained in pharmaceutical formulations (injection) and tap water spiked samples, were 9.65x10-7 mol L−1 and 1.23x10-6 mol L−1, respectively. The method is simple and does not require expensive instruments or complicated extraction steps of the reaction product
author	Soto,César A. Saavedra,Renato A. Poza,Cristian A. Contreras,David R. Oyarzún,Diego P. Toral,María I.
author_facet	Soto,César A. Saavedra,Renato A. Poza,Cristian A. Contreras,David R. Oyarzún,Diego P. Toral,María I.
author_sort	Soto,César A.
title	SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES
title_short	SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES
title_full	SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES
title_fullStr	SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES
title_full_unstemmed	SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES
title_sort	sensitive kinetic spectrophotometric method for the determination of diphenhydramine in real samples
publisher	Sociedad Chilena de Química
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304507
work_keys_str_mv	AT sotocesara sensitivekineticspectrophotometricmethodforthedeterminationofdiphenhydramineinrealsamples AT saavedrarenatoa sensitivekineticspectrophotometricmethodforthedeterminationofdiphenhydramineinrealsamples AT pozacristiana sensitivekineticspectrophotometricmethodforthedeterminationofdiphenhydramineinrealsamples AT contrerasdavidr sensitivekineticspectrophotometricmethodforthedeterminationofdiphenhydramineinrealsamples AT oyarzundiegop sensitivekineticspectrophotometricmethodforthedeterminationofdiphenhydramineinrealsamples AT toralmariai sensitivekineticspectrophotometricmethodforthedeterminationofdiphenhydramineinrealsamples
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SENSITIVE KINETIC SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF DIPHENHYDRAMINE IN REAL SAMPLES

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