APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID

ABSTRACT An analytical method based on vortex-assisted dispersive liquid-liquid microextraction and gas chromatography-flame ionization detection is presented for the extraction and determination of malondialdehyde) MDA (in blood plasma of human. Various parameters affecting the extraction efficienc...

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Autores principales:	Mirmoghaddam,Majid, Kaykhaii,Massoud, Hashemi,Mohammad, Keikha,Ahmad Jamali, Hashemi,Sayyed Hossein, Yahyavi,Hossein
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2019
Materias:	Malondialdehyde Vortex-assisted dispersive liquid-liquid microextraction Response surface methodology Human serum analysis GC-FID
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304531
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spelling	oai:scielo:S0717-970720190003045312019-11-06APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FIDMirmoghaddam,MajidKaykhaii,MassoudHashemi,MohammadKeikha,Ahmad JamaliHashemi,Sayyed HosseinYahyavi,Hossein Malondialdehyde Vortex-assisted dispersive liquid-liquid microextraction Response surface methodology Human serum analysis GC-FID ABSTRACT An analytical method based on vortex-assisted dispersive liquid-liquid microextraction and gas chromatography-flame ionization detection is presented for the extraction and determination of malondialdehyde) MDA (in blood plasma of human. Various parameters affecting the extraction efficiency such as type and volume of extraction and dispersive solvents, vortex and centrifuge times, volume, ionic strength and pH of the sample solution were evaluated using, one-variable-at-a-time and response surface methodology. In order to optimize the MDA extraction and determination, seven factors in five- levels were used for design of experiments (DOE). Under optimum extraction condition, this method showed linear range of calibration curve between 10–1150 μg L–1. The detection limit of the proposed method was found to be 0.8 μg L–1 with a relative standard deviation better than 5.5% (n=10) for blood serum samples. Enrichment factor was calculated to be 175 fold and the total analysis time including microextraction was about 13 min. The method was successfully applied for the analysis of MDA in blood plasma of human.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.64 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304531en10.4067/S0717-97072019000304531
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Malondialdehyde Vortex-assisted dispersive liquid-liquid microextraction Response surface methodology Human serum analysis GC-FID
spellingShingle	Malondialdehyde Vortex-assisted dispersive liquid-liquid microextraction Response surface methodology Human serum analysis GC-FID Mirmoghaddam,Majid Kaykhaii,Massoud Hashemi,Mohammad Keikha,Ahmad Jamali Hashemi,Sayyed Hossein Yahyavi,Hossein APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID
description	ABSTRACT An analytical method based on vortex-assisted dispersive liquid-liquid microextraction and gas chromatography-flame ionization detection is presented for the extraction and determination of malondialdehyde) MDA (in blood plasma of human. Various parameters affecting the extraction efficiency such as type and volume of extraction and dispersive solvents, vortex and centrifuge times, volume, ionic strength and pH of the sample solution were evaluated using, one-variable-at-a-time and response surface methodology. In order to optimize the MDA extraction and determination, seven factors in five- levels were used for design of experiments (DOE). Under optimum extraction condition, this method showed linear range of calibration curve between 10–1150 μg L–1. The detection limit of the proposed method was found to be 0.8 μg L–1 with a relative standard deviation better than 5.5% (n=10) for blood serum samples. Enrichment factor was calculated to be 175 fold and the total analysis time including microextraction was about 13 min. The method was successfully applied for the analysis of MDA in blood plasma of human.
author	Mirmoghaddam,Majid Kaykhaii,Massoud Hashemi,Mohammad Keikha,Ahmad Jamali Hashemi,Sayyed Hossein Yahyavi,Hossein
author_facet	Mirmoghaddam,Majid Kaykhaii,Massoud Hashemi,Mohammad Keikha,Ahmad Jamali Hashemi,Sayyed Hossein Yahyavi,Hossein
author_sort	Mirmoghaddam,Majid
title	APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID
title_short	APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID
title_full	APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID
title_fullStr	APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID
title_full_unstemmed	APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID
title_sort	application of response surface modeling for optimization and determination of malondialdialdehyde by vortex-assisted dispersive liquid-liquid microextraction and gc-fid
publisher	Sociedad Chilena de Química
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304531
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APPLICATION OF RESPONSE SURFACE MODELING FOR OPTIMIZATION AND DETERMINATION OF MALONDIALDIALDEHYDE BY VORTEX-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION AND GC-FID

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