SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONS

ABSTRACT Natural polymers have been widely used in different fields specifically in pharmaceutical industry due to their biocompatibility, biodegradability, and less toxicity properties. Among these polymers, chitosan is a potentially pursued biomaterial. However, limited solubility of chitosan in w...

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Autores principales: Bashir,Shahid, Teo,Yin Yin, Ramesh,S., Ramesh,K., Rizwan,Muhammad
Lenguaje:English
Publicado: Sociedad Chilena de Química 2019
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304571
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spelling oai:scielo:S0717-970720190003045712019-11-06SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONSBashir,ShahidTeo,Yin YinRamesh,S.Ramesh,K.Rizwan,MuhammadRizwan,Muhammad Hydrogel mechanical and swelling properties N-Succinyl chitosan ABSTRACT Natural polymers have been widely used in different fields specifically in pharmaceutical industry due to their biocompatibility, biodegradability, and less toxicity properties. Among these polymers, chitosan is a potentially pursued biomaterial. However, limited solubility of chitosan in water creates significant barrier in realizing its applications as a biomaterial. Modification of chitosan helps to overcome this barrier with improved solubility in water. In this study, N-succinyl chitosan was synthesized from the chemical reaction of chitosan and succinic anhydride via Schiff base mechanism by using glutaraldehyde as a crosslinking agent. N-succinyl chitosan is water soluble, biocompatible, biodegradable, and less toxic. The physico-chemical properties of NSC and prepared hydrogel were characterized by using Fourier transform infrared (FTIR) spectroscopy, Nuclear Magnetic Resonance Spectroscopy (NMR), X-ray diffraction (XRD) analysis, and differential scanning calorimetry (DSC). The surface morphology was investigated through Field emission scanning electron microscopy (FESEM). All these results confirmed the successful synthesis of N-succinyl chitosan and its hydrogel. Moreover, the mechanical properties of the hydrogel were evaluated using rheometer and found that hydrogel has significant potential to be used in the biomedical field. In addition, the swelling properties of the hydrogel were also studied in buffer solutions of pH 1.2 and 7.4. These results endorsed its applications as a drug delivery carrier.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.64 n.3 20192019-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304571en10.4067/S0717-97072019000304571
institution Scielo Chile
collection Scielo Chile
language English
topic Hydrogel
mechanical and swelling properties
N-Succinyl chitosan
spellingShingle Hydrogel
mechanical and swelling properties
N-Succinyl chitosan
Bashir,Shahid
Teo,Yin Yin
Ramesh,S.
Ramesh,K.
Rizwan,Muhammad
Rizwan,Muhammad
SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONS
description ABSTRACT Natural polymers have been widely used in different fields specifically in pharmaceutical industry due to their biocompatibility, biodegradability, and less toxicity properties. Among these polymers, chitosan is a potentially pursued biomaterial. However, limited solubility of chitosan in water creates significant barrier in realizing its applications as a biomaterial. Modification of chitosan helps to overcome this barrier with improved solubility in water. In this study, N-succinyl chitosan was synthesized from the chemical reaction of chitosan and succinic anhydride via Schiff base mechanism by using glutaraldehyde as a crosslinking agent. N-succinyl chitosan is water soluble, biocompatible, biodegradable, and less toxic. The physico-chemical properties of NSC and prepared hydrogel were characterized by using Fourier transform infrared (FTIR) spectroscopy, Nuclear Magnetic Resonance Spectroscopy (NMR), X-ray diffraction (XRD) analysis, and differential scanning calorimetry (DSC). The surface morphology was investigated through Field emission scanning electron microscopy (FESEM). All these results confirmed the successful synthesis of N-succinyl chitosan and its hydrogel. Moreover, the mechanical properties of the hydrogel were evaluated using rheometer and found that hydrogel has significant potential to be used in the biomedical field. In addition, the swelling properties of the hydrogel were also studied in buffer solutions of pH 1.2 and 7.4. These results endorsed its applications as a drug delivery carrier.
author Bashir,Shahid
Teo,Yin Yin
Ramesh,S.
Ramesh,K.
Rizwan,Muhammad
Rizwan,Muhammad
author_facet Bashir,Shahid
Teo,Yin Yin
Ramesh,S.
Ramesh,K.
Rizwan,Muhammad
Rizwan,Muhammad
author_sort Bashir,Shahid
title SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONS
title_short SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONS
title_full SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONS
title_fullStr SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONS
title_full_unstemmed SYNTHESIS AND CHARACTERIZATION OF pH-SENSITIVE N-SUCCINYL CHITOSAN HYDROGEL AND ITS PROPERTIES FOR BIOMEDICAL APPLICATIONS
title_sort synthesis and characterization of ph-sensitive n-succinyl chitosan hydrogel and its properties for biomedical applications
publisher Sociedad Chilena de Química
publishDate 2019
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000304571
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