INDUCTION OF C-MYC G-QUADRUPLEX DNA AND CYTOTOXICITY OF A CALIX[]ARENE-CONTAINING BINUCLEAR RUTHENIUM(II) COMPLEX

INDUCTION OF C-MYC G-QUADRUPLEX DNA AND CYTOTOXICITY OF A CALIX[]ARENE-CONTAINING BINUCLEAR RUTHENIUM(II) COMPLEX

ABSTRACT Herein, a binuclear ruthenium(II) complex modified by calix[4]arene group has been prepared. The complex as potential inducer and stabilizer of c-myc G-quadruplex DNA and antitumor reagent were studied. Observations revealed that the complex could bind to c-myc Pu27 and Pu22 DNA strongly wi...

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Autores principales: Mi,Ya-Xuan, Wang,Shuang, Yan,Shuang-Mei, Cui,Yue, Wang,Ming-He, Zheng,Ze-Bao, Zhao,Xiao-Long
Lenguaje:English
Publicado: Sociedad Chilena de Química 2019
Materias:
Ruthenium
c-myc G-quadruplex DNA
Topoisomerase
Cytotoxicity
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000404639
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