THIN-LAYER CHROMATOGRAPHY ON REVERSED PHASE IN THE CHARACTERIZATION OF RETENTION BEHAVIOUR, LIPOPHILICITY, AND PHARMACOKINETICS OF CYANOACETAMIDE DERIVATIVES

THIN-LAYER CHROMATOGRAPHY ON REVERSED PHASE IN THE CHARACTERIZATION OF RETENTION BEHAVIOUR, LIPOPHILICITY, AND PHARMACOKINETICS OF CYANOACETAMIDE DERIVATIVES

ABSTRACT Biological activity of a molecule is closely related to its lipophilicity. This significant parameter was determined for a group of potentially bioactive N-(4-phenylmonosubstituted)-2-cyanoacetamides applying thin-layer chromatography on reversed phase (RP-TLC) in mixtures of water and two...

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Autores principales: Apostolov,Suzana, Vastag,Gyöngyi, Matijević,Borko, Đaković-Sekulić,Tatjana, Marinković,Aleksandar
Lenguaje:English
Publicado: Sociedad Chilena de Química 2020
Materias:
N-(4-phenylmonosubstituted)-2-cyanoacetamides
RP-TLC
lipophilicity
Lipinski's molecular descriptors
pharmacokinetic predictors
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104654
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