ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES

ABSTRACT N,N-dimethyltryptamine (DMT) is a short-acting psychotropic agent when administered parenterally and is not active orally due to its rapid degradation by monoamine oxidase enzyme type A. There is growing interest in the therapeutic potential of DMT due to recent clinical data that has shown...

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Autores principales:	Plaza,Gonzalo, Piña,Benjamín, Herrera,Heidy, Calfuman,Karla
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Tetraruthenated porphyrins Modified electrodes DMT Ionic Liquids
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104668
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spelling	oai:scielo:S0717-970720200001046682020-04-16ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODESPlaza,GonzaloPiña,BenjamínHerrera,HeidyCalfuman,Karla Tetraruthenated porphyrins Modified electrodes DMT Ionic Liquids ABSTRACT N,N-dimethyltryptamine (DMT) is a short-acting psychotropic agent when administered parenterally and is not active orally due to its rapid degradation by monoamine oxidase enzyme type A. There is growing interest in the therapeutic potential of DMT due to recent clinical data that has shown that produces antidepressant effects in humans. It has also been found that psychedelics that possess the central structure of DMT may have value as medications and cannot simply be labeled as drugs with the potential for abuse. The incorporation of ionic liquid and tetraruthenated zinc porphyrin to glassy carbon electrode enhanced the voltammetric determination of DMT compared to the bare glassy carbon electrode. These modified electrodes showed good performance for DMT oxidation. These results translate into a low detection limit (1.75 µM), short response time, satisfactory linear concentration range, very good stability and reproducibility. Thus, his methodology can be a feasible and inexpensive way to detect DMT in water and presents potential to be applied in the detection of DMT in urine.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.1 20202020-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104668en10.4067/S0717-97072020000104668
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Tetraruthenated porphyrins Modified electrodes DMT Ionic Liquids
spellingShingle	Tetraruthenated porphyrins Modified electrodes DMT Ionic Liquids Plaza,Gonzalo Piña,Benjamín Herrera,Heidy Calfuman,Karla ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES
description	ABSTRACT N,N-dimethyltryptamine (DMT) is a short-acting psychotropic agent when administered parenterally and is not active orally due to its rapid degradation by monoamine oxidase enzyme type A. There is growing interest in the therapeutic potential of DMT due to recent clinical data that has shown that produces antidepressant effects in humans. It has also been found that psychedelics that possess the central structure of DMT may have value as medications and cannot simply be labeled as drugs with the potential for abuse. The incorporation of ionic liquid and tetraruthenated zinc porphyrin to glassy carbon electrode enhanced the voltammetric determination of DMT compared to the bare glassy carbon electrode. These modified electrodes showed good performance for DMT oxidation. These results translate into a low detection limit (1.75 µM), short response time, satisfactory linear concentration range, very good stability and reproducibility. Thus, his methodology can be a feasible and inexpensive way to detect DMT in water and presents potential to be applied in the detection of DMT in urine.
author	Plaza,Gonzalo Piña,Benjamín Herrera,Heidy Calfuman,Karla
author_facet	Plaza,Gonzalo Piña,Benjamín Herrera,Heidy Calfuman,Karla
author_sort	Plaza,Gonzalo
title	ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES
title_short	ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES
title_full	ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES
title_fullStr	ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES
title_full_unstemmed	ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES
title_sort	electrochemical determination of n,n-dimethyltryptamine in water based on tetraruthenated porphyrins and ionic liquid modified electrodes
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104668
work_keys_str_mv	AT plazagonzalo electrochemicaldeterminationofnndimethyltryptamineinwaterbasedontetraruthenatedporphyrinsandionicliquidmodifiedelectrodes AT pinabenjamin electrochemicaldeterminationofnndimethyltryptamineinwaterbasedontetraruthenatedporphyrinsandionicliquidmodifiedelectrodes AT herreraheidy electrochemicaldeterminationofnndimethyltryptamineinwaterbasedontetraruthenatedporphyrinsandionicliquidmodifiedelectrodes AT calfumankarla electrochemicaldeterminationofnndimethyltryptamineinwaterbasedontetraruthenatedporphyrinsandionicliquidmodifiedelectrodes
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ELECTROCHEMICAL DETERMINATION OF N,N-DIMETHYLTRYPTAMINE IN WATER BASED ON TETRARUTHENATED PORPHYRINS AND IONIC LIQUID MODIFIED ELECTRODES

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