SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS

ABSTRACT Lanthanide-doped gadolinium nanomaterials have attracted considerable attention due to their promising applications in biological imaging. Sodium gadolinium fluoride (β-NaGdF4) nanomaterials act as perfect host for doping of luminescent lanthanide ions. Due to heavy nature of gadol...

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Autores principales:	Rashid,Haroon Ur, Yaseen,Muhammad, Riaz,Ali, Khan,Kamin, Rahman,Hanif Ur, Khan,Khalid, Ahmad,Nasir, Utrera Martines,Marco Antonio
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	lanthanide nanocrystals trimodal gadolinium contrast agents
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104717
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spelling	oai:scielo:S0717-970720200001047172020-04-16SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTSRashid,Haroon UrYaseen,MuhammadRiaz,AliKhan,KaminRahman,Hanif UrKhan,KhalidAhmad,NasirUtrera Martines,Marco Antonio lanthanide nanocrystals trimodal gadolinium contrast agents ABSTRACT Lanthanide-doped gadolinium nanomaterials have attracted considerable attention due to their promising applications in biological imaging. Sodium gadolinium fluoride (β-NaGdF4) nanomaterials act as perfect host for doping of luminescent lanthanide ions. Due to heavy nature of gadolinium, it can strongly absorb X-ray radiations. Therefore, Gd-based nanomaterials are applied as contrast agents for X-ray tomography (CT). Presence of seven unpaired electrons in Gd+3 ion, its large magnetic moment and long electronic relaxation time makes it an ideal candidate to enhance water proton relaxation rates. These characteristics make Gd-based nanomaterial useful for their potential application as MRI contrast agents. In this work, sodium gadolinium fluoride is doped with ytterbium and erbium to produce β-NaGdF4:Yb/Er as core nanocrystals. They are subsequently coated with sodium gadolinium fluoride doped with neodymium (β-NaGdF4:Nd) to produce β-NaGdF4:Yb/Er@β-NaGdF4:Nd core-shell nanocrystals. Powder X‐ray diffraction (XRD) results indicated that β-NaGdF4 (host), β-NaGdF4:Yb/Er (core) and β-NaGdF4:Yb/Er@β-NaGdF4:Nd (core-shell) nanocrystals all exist in hexagonal crystalline phase. While Dynamic Light Scattering (DLS) results indicated that the particle size of the synthesized nanocrystals was in range of 12 to 27 nm. FTIR results confirmed that the synthesized nanocrystals were stabilized by oleic acid. Nanocrystals reported in this work are expected to be useful trimodal contrast agents for photoluminescence, X-ray tomography and Magnetic Resonance Imaging (MRI).info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.1 20202020-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104717en10.4067/S0717-97072020000104717
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	lanthanide nanocrystals trimodal gadolinium contrast agents
spellingShingle	lanthanide nanocrystals trimodal gadolinium contrast agents Rashid,Haroon Ur Yaseen,Muhammad Riaz,Ali Khan,Kamin Rahman,Hanif Ur Khan,Khalid Ahmad,Nasir Utrera Martines,Marco Antonio SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS
description	ABSTRACT Lanthanide-doped gadolinium nanomaterials have attracted considerable attention due to their promising applications in biological imaging. Sodium gadolinium fluoride (β-NaGdF4) nanomaterials act as perfect host for doping of luminescent lanthanide ions. Due to heavy nature of gadolinium, it can strongly absorb X-ray radiations. Therefore, Gd-based nanomaterials are applied as contrast agents for X-ray tomography (CT). Presence of seven unpaired electrons in Gd+3 ion, its large magnetic moment and long electronic relaxation time makes it an ideal candidate to enhance water proton relaxation rates. These characteristics make Gd-based nanomaterial useful for their potential application as MRI contrast agents. In this work, sodium gadolinium fluoride is doped with ytterbium and erbium to produce β-NaGdF4:Yb/Er as core nanocrystals. They are subsequently coated with sodium gadolinium fluoride doped with neodymium (β-NaGdF4:Nd) to produce β-NaGdF4:Yb/Er@β-NaGdF4:Nd core-shell nanocrystals. Powder X‐ray diffraction (XRD) results indicated that β-NaGdF4 (host), β-NaGdF4:Yb/Er (core) and β-NaGdF4:Yb/Er@β-NaGdF4:Nd (core-shell) nanocrystals all exist in hexagonal crystalline phase. While Dynamic Light Scattering (DLS) results indicated that the particle size of the synthesized nanocrystals was in range of 12 to 27 nm. FTIR results confirmed that the synthesized nanocrystals were stabilized by oleic acid. Nanocrystals reported in this work are expected to be useful trimodal contrast agents for photoluminescence, X-ray tomography and Magnetic Resonance Imaging (MRI).
author	Rashid,Haroon Ur Yaseen,Muhammad Riaz,Ali Khan,Kamin Rahman,Hanif Ur Khan,Khalid Ahmad,Nasir Utrera Martines,Marco Antonio
author_facet	Rashid,Haroon Ur Yaseen,Muhammad Riaz,Ali Khan,Kamin Rahman,Hanif Ur Khan,Khalid Ahmad,Nasir Utrera Martines,Marco Antonio
author_sort	Rashid,Haroon Ur
title	SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS
title_short	SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS
title_full	SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS
title_fullStr	SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS
title_full_unstemmed	SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS
title_sort	synthesis and characterization of gadolinium-based nanocrystals for their potential application as trimodal imaging contrast agents
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104717
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SYNTHESIS AND CHARACTERIZATION OF GADOLINIUM-BASED NANOCRYSTALS FOR THEIR POTENTIAL APPLICATION AS TRIMODAL IMAGING CONTRAST AGENTS

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