ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK

ABSTRACT Polybrominated diphenyl ethers (PBDEs), which are used as flame retardants, are widely used additives so many different kind of materials that are consumed by public. Current researches reveal a significant increase in the levels of PBDEs in human biological fluids all around the world. Acc...

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Autores principales:	Sagiroglu,Ali Asram, Tekkeli,Serife Evrim Kepekci, Onal,Cem, Dincel,Demet, Onal,Armagan
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	PBDE breast milk analytical methods extraction technique organobromomine compounds chemical pollutant
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104726
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spelling	oai:scielo:S0717-970720200001047262020-04-16ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILKSagiroglu,Ali AsramTekkeli,Serife Evrim KepekciOnal,CemDincel,DemetOnal,Armagan PBDE breast milk analytical methods extraction technique organobromomine compounds chemical pollutant ABSTRACT Polybrominated diphenyl ethers (PBDEs), which are used as flame retardants, are widely used additives so many different kind of materials that are consumed by public. Current researches reveal a significant increase in the levels of PBDEs in human biological fluids all around the world. According to International Agency for Research on Cancer (IARC), PBDEs are declarated as carcinogenic agents and additionally a considerable risks have been shown in animal studies such as liver damage, alteration of thyroid hormone levels, neurotoxicity and hazardous effects on development of fetus. Due to the simplicity of human exposure routes such as ingestion, inhalation or dermal contact, it gains high importance to quantify PBDEs in biological fluids. The exposure to PBDEs is critic aspecially during pregnancy, fetus development and infancy. Excretion of PBDEs in human milk is the focus area for researchers in recent years. In this study, we reviewed current methodologies for the determination of PBDEs in human milk including sample preparation step, analytical procedure, validation parameters and observed levels of PBDEs in human milk. Because of the high physico-chemical stability of PBDEs, they have long persistence in human body. Besides, they reside in the lipid fractions of tissues because of their hydrophobic characteristics. Human breast milk has high lipid level, so that it is a suitable matrix for the accumulation and determination of PBDEs.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.1 20202020-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104726en10.4067/S0717-97072020000104726
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	PBDE breast milk analytical methods extraction technique organobromomine compounds chemical pollutant
spellingShingle	PBDE breast milk analytical methods extraction technique organobromomine compounds chemical pollutant Sagiroglu,Ali Asram Tekkeli,Serife Evrim Kepekci Onal,Cem Dincel,Demet Onal,Armagan ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK
description	ABSTRACT Polybrominated diphenyl ethers (PBDEs), which are used as flame retardants, are widely used additives so many different kind of materials that are consumed by public. Current researches reveal a significant increase in the levels of PBDEs in human biological fluids all around the world. According to International Agency for Research on Cancer (IARC), PBDEs are declarated as carcinogenic agents and additionally a considerable risks have been shown in animal studies such as liver damage, alteration of thyroid hormone levels, neurotoxicity and hazardous effects on development of fetus. Due to the simplicity of human exposure routes such as ingestion, inhalation or dermal contact, it gains high importance to quantify PBDEs in biological fluids. The exposure to PBDEs is critic aspecially during pregnancy, fetus development and infancy. Excretion of PBDEs in human milk is the focus area for researchers in recent years. In this study, we reviewed current methodologies for the determination of PBDEs in human milk including sample preparation step, analytical procedure, validation parameters and observed levels of PBDEs in human milk. Because of the high physico-chemical stability of PBDEs, they have long persistence in human body. Besides, they reside in the lipid fractions of tissues because of their hydrophobic characteristics. Human breast milk has high lipid level, so that it is a suitable matrix for the accumulation and determination of PBDEs.
author	Sagiroglu,Ali Asram Tekkeli,Serife Evrim Kepekci Onal,Cem Dincel,Demet Onal,Armagan
author_facet	Sagiroglu,Ali Asram Tekkeli,Serife Evrim Kepekci Onal,Cem Dincel,Demet Onal,Armagan
author_sort	Sagiroglu,Ali Asram
title	ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK
title_short	ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK
title_full	ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK
title_fullStr	ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK
title_full_unstemmed	ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK
title_sort	analytical methods for the determination of polybrominated diphenyl ethers in human milk
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104726
work_keys_str_mv	AT sagiroglualiasram analyticalmethodsforthedeterminationofpolybrominateddiphenylethersinhumanmilk AT tekkeliserifeevrimkepekci analyticalmethodsforthedeterminationofpolybrominateddiphenylethersinhumanmilk AT onalcem analyticalmethodsforthedeterminationofpolybrominateddiphenylethersinhumanmilk AT dinceldemet analyticalmethodsforthedeterminationofpolybrominateddiphenylethersinhumanmilk AT onalarmagan analyticalmethodsforthedeterminationofpolybrominateddiphenylethersinhumanmilk
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ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK

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