PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEW
ABSTRACT Pyrazole being a heterocyclic motif has secured an eccentric status in the field of medicinal chemistry. Pyrazole and its derivatives have tremendous biological applications like anti-cancer, anti-microbial, antiviral, antifungal, anti-inflammatory, analgesic, insecticidal etc. In this revi...
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Sociedad Chilena de Química
2020
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oai:scielo:S0717-970720200001047462020-04-16PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEWAziz,HiraZahoor,Ameer FawadAhmad,Sajjad Anticancer activity Antimicrobial activity Anti-inflammatory/analgesic activity Insecticidal activity Anti-enzymatic Pyrazole ABSTRACT Pyrazole being a heterocyclic motif has secured an eccentric status in the field of medicinal chemistry. Pyrazole and its derivatives have tremendous biological applications like anti-cancer, anti-microbial, antiviral, antifungal, anti-inflammatory, analgesic, insecticidal etc. In this review, some recent developments have been reported for the synthesis of biologically active pyrazole based molecules having biological potential such as anti-SIRT1 and SIRT2, anti-FAAH, anti-NOSs, as liver X receptor partial agonist, CB2 receptor ligand and glucagon receptor antagonists.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.1 20202020-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104746en10.4067/S0717-97072020000104746 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Anticancer activity Antimicrobial activity Anti-inflammatory/analgesic activity Insecticidal activity Anti-enzymatic Pyrazole |
| spellingShingle |
Anticancer activity Antimicrobial activity Anti-inflammatory/analgesic activity Insecticidal activity Anti-enzymatic Pyrazole Aziz,Hira Zahoor,Ameer Fawad Ahmad,Sajjad PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEW |
| description |
ABSTRACT Pyrazole being a heterocyclic motif has secured an eccentric status in the field of medicinal chemistry. Pyrazole and its derivatives have tremendous biological applications like anti-cancer, anti-microbial, antiviral, antifungal, anti-inflammatory, analgesic, insecticidal etc. In this review, some recent developments have been reported for the synthesis of biologically active pyrazole based molecules having biological potential such as anti-SIRT1 and SIRT2, anti-FAAH, anti-NOSs, as liver X receptor partial agonist, CB2 receptor ligand and glucagon receptor antagonists. |
| author |
Aziz,Hira Zahoor,Ameer Fawad Ahmad,Sajjad |
| author_facet |
Aziz,Hira Zahoor,Ameer Fawad Ahmad,Sajjad |
| author_sort |
Aziz,Hira |
| title |
PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEW |
| title_short |
PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEW |
| title_full |
PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEW |
| title_fullStr |
PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEW |
| title_full_unstemmed |
PYRAZOLE BEARING MOLECULES AS BIOACTIVE SCAFFOLDS: A REVIEW |
| title_sort |
pyrazole bearing molecules as bioactive scaffolds: a review |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000104746 |
| work_keys_str_mv |
AT azizhira pyrazolebearingmoleculesasbioactivescaffoldsareview AT zahoorameerfawad pyrazolebearingmoleculesasbioactivescaffoldsareview AT ahmadsajjad pyrazolebearingmoleculesasbioactivescaffoldsareview |
| _version_ |
1714200946505940992 |