SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS

ABSTRACT Four new Schiff-base hydrazone ligands were synthesized by the condensation of 2- and 4-aminobenzoylhydrazone with 3-(4-acetylphenoxy)-N,N,N-trimethylpropane-1-ammonium and 5-(4-acetylphenoxy)-N,N,N-trimethylpentane-1-ammonium salts. The structures of the ligands were confirmed by means of...

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Autores principales:	Şengül,Elif Eda, Göktürk,Tolga, Topkaya,Cansu Gökçe, Gup,Ramazan
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Hydrazone quaternary ammonium salts mono- and binuclear copper(II) complex DNA binding and cleavage
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204754
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spelling	oai:scielo:S0717-970720200002047542020-08-14SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTSŞengül,Elif EdaGöktürk,TolgaTopkaya,Cansu GökçeGup,Ramazan Hydrazone quaternary ammonium salts mono- and binuclear copper(II) complex DNA binding and cleavage ABSTRACT Four new Schiff-base hydrazone ligands were synthesized by the condensation of 2- and 4-aminobenzoylhydrazone with 3-(4-acetylphenoxy)-N,N,N-trimethylpropane-1-ammonium and 5-(4-acetylphenoxy)-N,N,N-trimethylpentane-1-ammonium salts. The structures of the ligands were confirmed by means of NMR, FTIR, and elemental analysis. The mononuclear and binuclear copper complexes containing these ligands were also obtained. The hydrazine-Schiff base compounds behave either as bidentate (NO sites) monobasic or tridentate (NNO sites) dibasic as ligands depending on the position of the amino group. Elemental analyses, magnetic susceptibility, FTIR and mass spectroscopy were used to confirm the proposed structures of new copper complexes. DNA binding and cleavage activities of all compounds were investigated. UV-vis spectroscopy results suggest that all compounds preferably bind to DNA via intercalation mode. According to the results of electrophoresis studies, the compounds exhibit significant cleavage activity on the plasmid DNA both in the absence and presence of hydrogen peroxide, depending on the concentration of the compounds.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.2 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204754en10.4067/S0717-97072020000204754
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hydrazone quaternary ammonium salts mono- and binuclear copper(II) complex DNA binding and cleavage
spellingShingle	Hydrazone quaternary ammonium salts mono- and binuclear copper(II) complex DNA binding and cleavage Şengül,Elif Eda Göktürk,Tolga Topkaya,Cansu Gökçe Gup,Ramazan SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS
description	ABSTRACT Four new Schiff-base hydrazone ligands were synthesized by the condensation of 2- and 4-aminobenzoylhydrazone with 3-(4-acetylphenoxy)-N,N,N-trimethylpropane-1-ammonium and 5-(4-acetylphenoxy)-N,N,N-trimethylpentane-1-ammonium salts. The structures of the ligands were confirmed by means of NMR, FTIR, and elemental analysis. The mononuclear and binuclear copper complexes containing these ligands were also obtained. The hydrazine-Schiff base compounds behave either as bidentate (NO sites) monobasic or tridentate (NNO sites) dibasic as ligands depending on the position of the amino group. Elemental analyses, magnetic susceptibility, FTIR and mass spectroscopy were used to confirm the proposed structures of new copper complexes. DNA binding and cleavage activities of all compounds were investigated. UV-vis spectroscopy results suggest that all compounds preferably bind to DNA via intercalation mode. According to the results of electrophoresis studies, the compounds exhibit significant cleavage activity on the plasmid DNA both in the absence and presence of hydrogen peroxide, depending on the concentration of the compounds.
author	Şengül,Elif Eda Göktürk,Tolga Topkaya,Cansu Gökçe Gup,Ramazan
author_facet	Şengül,Elif Eda Göktürk,Tolga Topkaya,Cansu Gökçe Gup,Ramazan
author_sort	Şengül,Elif Eda
title	SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS
title_short	SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS
title_full	SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS
title_fullStr	SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS
title_full_unstemmed	SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS
title_sort	synthesis, characterization and dna interaction of cu(ii) complexes with hydrazone-schiff base ligands bearing alkyl quaternary ammonium salts
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204754
work_keys_str_mv	AT 350engulelifeda synthesischaracterizationanddnainteractionofcuiicomplexeswithhydrazoneschiffbaseligandsbearingalkylquaternaryammoniumsalts AT gokturktolga synthesischaracterizationanddnainteractionofcuiicomplexeswithhydrazoneschiffbaseligandsbearingalkylquaternaryammoniumsalts AT topkayacansugokce synthesischaracterizationanddnainteractionofcuiicomplexeswithhydrazoneschiffbaseligandsbearingalkylquaternaryammoniumsalts AT gupramazan synthesischaracterizationanddnainteractionofcuiicomplexeswithhydrazoneschiffbaseligandsbearingalkylquaternaryammoniumsalts
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SYNTHESIS, CHARACTERIZATION AND DNA INTERACTION OF CU(II) COMPLEXES WITH HYDRAZONE-SCHIFF BASE LIGANDS BEARING ALKYL QUATERNARY AMMONIUM SALTS

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