ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE

ABSTRACT Currently, some quinoline-based anticancer drugs are successful repurposed for treatment of bacterial infections. This study assessed the antibacterial activity of the new anticancer compound 4,7-dichloro-2-quinolinemethylacrylate (AQM) against bacteria of both clinical and agricultural int...

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Autores principales:	Valle,Hernán, Viswanathan Mangalaraja,Ramalinga, Aguilar,Luis, Carrasco,Carlos, Padilla,Natalia, Dahrouch,Mohamed, Rivas,Bernabé, Urrutia,Homero
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Quinoline antibacterial activity fluorescence quenching broth microdilution
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204784
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spelling	oai:scielo:S0717-970720200002047842020-08-14ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATEValle,HernánViswanathan Mangalaraja,RamalingaAguilar,LuisCarrasco,CarlosPadilla,NataliaDahrouch,MohamedRivas,BernabéUrrutia,Homero Quinoline antibacterial activity fluorescence quenching broth microdilution ABSTRACT Currently, some quinoline-based anticancer drugs are successful repurposed for treatment of bacterial infections. This study assessed the antibacterial activity of the new anticancer compound 4,7-dichloro-2-quinolinemethylacrylate (AQM) against bacteria of both clinical and agricultural interest, and also determined the influence of some metal cations (Fe3+, Mn2+, Zn2+, Na+, Mg2+, Co2+ and Ni2+) on the AQM photophysics. The synthesis of AQM was carried out by the reported method. The antibacterial activity of AQM on Pectobacterium carotovorum subsp. carotovorum (Pcc), Ralstonia solanacearum, Klebsiella pneuminiae, Pseudomonas syringae, Staphylococcus aureus y Bacillus sp., was evaluated using the spectrophotometric method of broth microdilution. At 125 ppm, AQM produced growth inhibition of 51.7% in Pcc, and a bacteriostatic effect in S. aureus and Bacillus sp., but no effect was seen against the other bacteria. In addition, fluorescence quenching of AQM solution induced only by Fe3+ ion, and not by the other metal cations, was confirmed. These results postulate that AQM could be a molecule with potential application in antibacterial therapy or in the fluorometric detection of Fe3+ ions.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.2 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204784en10.4067/S0717-97072020000204784
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Quinoline antibacterial activity fluorescence quenching broth microdilution
spellingShingle	Quinoline antibacterial activity fluorescence quenching broth microdilution Valle,Hernán Viswanathan Mangalaraja,Ramalinga Aguilar,Luis Carrasco,Carlos Padilla,Natalia Dahrouch,Mohamed Rivas,Bernabé Urrutia,Homero ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE
description	ABSTRACT Currently, some quinoline-based anticancer drugs are successful repurposed for treatment of bacterial infections. This study assessed the antibacterial activity of the new anticancer compound 4,7-dichloro-2-quinolinemethylacrylate (AQM) against bacteria of both clinical and agricultural interest, and also determined the influence of some metal cations (Fe3+, Mn2+, Zn2+, Na+, Mg2+, Co2+ and Ni2+) on the AQM photophysics. The synthesis of AQM was carried out by the reported method. The antibacterial activity of AQM on Pectobacterium carotovorum subsp. carotovorum (Pcc), Ralstonia solanacearum, Klebsiella pneuminiae, Pseudomonas syringae, Staphylococcus aureus y Bacillus sp., was evaluated using the spectrophotometric method of broth microdilution. At 125 ppm, AQM produced growth inhibition of 51.7% in Pcc, and a bacteriostatic effect in S. aureus and Bacillus sp., but no effect was seen against the other bacteria. In addition, fluorescence quenching of AQM solution induced only by Fe3+ ion, and not by the other metal cations, was confirmed. These results postulate that AQM could be a molecule with potential application in antibacterial therapy or in the fluorometric detection of Fe3+ ions.
author	Valle,Hernán Viswanathan Mangalaraja,Ramalinga Aguilar,Luis Carrasco,Carlos Padilla,Natalia Dahrouch,Mohamed Rivas,Bernabé Urrutia,Homero
author_facet	Valle,Hernán Viswanathan Mangalaraja,Ramalinga Aguilar,Luis Carrasco,Carlos Padilla,Natalia Dahrouch,Mohamed Rivas,Bernabé Urrutia,Homero
author_sort	Valle,Hernán
title	ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE
title_short	ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE
title_full	ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE
title_fullStr	ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE
title_full_unstemmed	ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE
title_sort	antibacterial activity and fluorescence properties of 4,7-dichloro-2-quinolinemethylacrylate
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204784
work_keys_str_mv	AT vallehernan antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate AT viswanathanmangalarajaramalinga antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate AT aguilarluis antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate AT carrascocarlos antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate AT padillanatalia antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate AT dahrouchmohamed antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate AT rivasbernabe antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate AT urrutiahomero antibacterialactivityandfluorescencepropertiesof47dichloro2quinolinemethylacrylate
_version_	1714200947329073152

ANTIBACTERIAL ACTIVITY AND FLUORESCENCE PROPERTIES OF 4,7-DICHLORO-2-QUINOLINEMETHYLACRYLATE

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