Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE

ABSTRACT In this study, cobalt ferrite nanomaterial with inverse spinel structure was synthesized via a co-precipitation method using Co(NO3)3.6H2O and Fe(NO3)3.9H2O. A 15% NH4OH solution was used as an alkaline agent for pH adjustment. Oleic acid was used as a coating agent on the surface of the sy...

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Autores principales:	Kafi-Ahmadi,Leila, Khademinia,Shahin, Najafzadeh Nansa,Mehrin, Alemi,Abdol Ali, Mahdavi,Majid, Poursattar Marjani,Ahmad
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Chronic Myeloid Leukemia (CML) CoFe2O4 Co-precipitation; K562 cell Nanoparticles
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204845
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spelling	oai:scielo:S0717-970720200002048452020-08-14Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINEKafi-Ahmadi,LeilaKhademinia,ShahinNajafzadeh Nansa,MehrinAlemi,Abdol AliMahdavi,MajidPoursattar Marjani,Ahmad Chronic Myeloid Leukemia (CML) CoFe2O4 Co-precipitation; K562 cell Nanoparticles ABSTRACT In this study, cobalt ferrite nanomaterial with inverse spinel structure was synthesized via a co-precipitation method using Co(NO3)3.6H2O and Fe(NO3)3.9H2O. A 15% NH4OH solution was used as an alkaline agent for pH adjustment. Oleic acid was used as a coating agent on the surface of the synthesized cobalt ferrite nanoparticles. PXRD analysis confirmed that the obtained material had a main CoFe2O4 cubic crystal structure with space group Fd-3m and lattice parameters a=b=c= 8.40 Å (JCPDS standard card no = 01-077-0426). According to the SEM analysis, the pseudo-spherical particles size distribution and morphology of the as-synthesized nanomaterial were homogeneous. The magnetic behavior of the obtained material was analyzed by vibrating-sample magnetometer (VSM). Besides, anti-cancer effect of the as-synthesized cobalt ferrite nanoparticles was examined on an experimental model of acute myeloid leukemia (CML) K562 cell line for the first time. Inhibition of cell growth and cytotoxicity (apoptosis) that are characteristics features of cobalt ferrite nanoparticles are tested on K562 cell line. The results showed growth and viability inhibition and induction of apoptosis in K562 cells treated with the nanoparticles.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.2 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204845en10.4067/S0717-97072020000204845
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Chronic Myeloid Leukemia (CML) CoFe2O4 Co-precipitation; K562 cell Nanoparticles
spellingShingle	Chronic Myeloid Leukemia (CML) CoFe2O4 Co-precipitation; K562 cell Nanoparticles Kafi-Ahmadi,Leila Khademinia,Shahin Najafzadeh Nansa,Mehrin Alemi,Abdol Ali Mahdavi,Majid Poursattar Marjani,Ahmad Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE
description	ABSTRACT In this study, cobalt ferrite nanomaterial with inverse spinel structure was synthesized via a co-precipitation method using Co(NO3)3.6H2O and Fe(NO3)3.9H2O. A 15% NH4OH solution was used as an alkaline agent for pH adjustment. Oleic acid was used as a coating agent on the surface of the synthesized cobalt ferrite nanoparticles. PXRD analysis confirmed that the obtained material had a main CoFe2O4 cubic crystal structure with space group Fd-3m and lattice parameters a=b=c= 8.40 Å (JCPDS standard card no = 01-077-0426). According to the SEM analysis, the pseudo-spherical particles size distribution and morphology of the as-synthesized nanomaterial were homogeneous. The magnetic behavior of the obtained material was analyzed by vibrating-sample magnetometer (VSM). Besides, anti-cancer effect of the as-synthesized cobalt ferrite nanoparticles was examined on an experimental model of acute myeloid leukemia (CML) K562 cell line for the first time. Inhibition of cell growth and cytotoxicity (apoptosis) that are characteristics features of cobalt ferrite nanoparticles are tested on K562 cell line. The results showed growth and viability inhibition and induction of apoptosis in K562 cells treated with the nanoparticles.
author	Kafi-Ahmadi,Leila Khademinia,Shahin Najafzadeh Nansa,Mehrin Alemi,Abdol Ali Mahdavi,Majid Poursattar Marjani,Ahmad
author_facet	Kafi-Ahmadi,Leila Khademinia,Shahin Najafzadeh Nansa,Mehrin Alemi,Abdol Ali Mahdavi,Majid Poursattar Marjani,Ahmad
author_sort	Kafi-Ahmadi,Leila
title	Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE
title_short	Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE
title_full	Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE
title_fullStr	Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE
title_full_unstemmed	Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE
title_sort	co-precipitation synthesis, characterization of cofe2o4 nanomaterial and evaluation of its toxicity behavior on human leukemia cancer k562 cell line
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000204845
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_version_	1714200948628258816

Co-PRECIPITATION SYNTHESIS, CHARACTERIZATION OF CoFE2O4 NANOMATERIAL AND EVALUATION OF ITS TOXICITY BEHAVIOR ON HUMAN LEUKEMIA CANCER K562 CELL LINE

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