SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN

ABSTRACT A new levofloxacin derivative using silver triflate with antibacterial activity was synthesized and characterized. The new compound has been physicochemically characterized through elemental analysis, spectroscopic and thermal methods. All correlated experimental data suggested that the lev...

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Autores principales:	Rusu,Aura, Imre,Silvia, Mare,Anca Delia, Lungu,Ioana-Andreea, Pascu,Georgiana-Andreea, Uivarosi,Valentina
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	levofloxacin triflate silver triflate antibacterial antibiotic resistance
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304857
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spelling	oai:scielo:S0717-970720200003048572020-10-09SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACINRusu,AuraImre,SilviaMare,Anca DeliaLungu,Ioana-AndreeaPascu,Georgiana-AndreeaUivarosi,Valentina levofloxacin triflate silver triflate antibacterial antibiotic resistance ABSTRACT A new levofloxacin derivative using silver triflate with antibacterial activity was synthesized and characterized. The new compound has been physicochemically characterized through elemental analysis, spectroscopic and thermal methods. All correlated experimental data suggested that the levofloxacin triflate was obtained. The antibacterial activity of the new compound was tested against six Gram-positive and Gram-negative bacteria. In vitro, the new compound had similar activity to levofloxacin against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and very closed to the minimum inhibitory concentration values of levofloxacin against Staphylococcus aureus MRSA, Enterococcus faecalis, and Pseudomonas aeruginosa.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.3 20202020-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304857en10.4067/s0717-97072020000204857
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	levofloxacin triflate silver triflate antibacterial antibiotic resistance
spellingShingle	levofloxacin triflate silver triflate antibacterial antibiotic resistance Rusu,Aura Imre,Silvia Mare,Anca Delia Lungu,Ioana-Andreea Pascu,Georgiana-Andreea Uivarosi,Valentina SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN
description	ABSTRACT A new levofloxacin derivative using silver triflate with antibacterial activity was synthesized and characterized. The new compound has been physicochemically characterized through elemental analysis, spectroscopic and thermal methods. All correlated experimental data suggested that the levofloxacin triflate was obtained. The antibacterial activity of the new compound was tested against six Gram-positive and Gram-negative bacteria. In vitro, the new compound had similar activity to levofloxacin against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and very closed to the minimum inhibitory concentration values of levofloxacin against Staphylococcus aureus MRSA, Enterococcus faecalis, and Pseudomonas aeruginosa.
author	Rusu,Aura Imre,Silvia Mare,Anca Delia Lungu,Ioana-Andreea Pascu,Georgiana-Andreea Uivarosi,Valentina
author_facet	Rusu,Aura Imre,Silvia Mare,Anca Delia Lungu,Ioana-Andreea Pascu,Georgiana-Andreea Uivarosi,Valentina
author_sort	Rusu,Aura
title	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN
title_short	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN
title_full	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN
title_fullStr	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN
title_full_unstemmed	SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN
title_sort	synthesis, characterization and antibacterial activity of a new derivative of levofloxacin
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304857
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SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN

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