CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR

ABSTRACT Nerve regeneration is a biologically complex phenomenon. Once the nervous system is damaged, its recovery is difficult and causes a malfunction in other parts of the body that can occur because mature neurons do not suffer cell division. To increase the prospects of axonal regeneration and...

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Autores principales:	Cárdenas-Triviño,Galo, Soto-Seguel,Rodrigo
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Neuronal tubes chitosan calcium glutamate polylactic acid freeze- dried
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304870
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spelling	oai:scielo:S0717-970720200003048702020-10-09CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIRCárdenas-Triviño,GaloSoto-Seguel,Rodrigo Neuronal tubes chitosan calcium glutamate polylactic acid freeze- dried ABSTRACT Nerve regeneration is a biologically complex phenomenon. Once the nervous system is damaged, its recovery is difficult and causes a malfunction in other parts of the body that can occur because mature neurons do not suffer cell division. To increase the prospects of axonal regeneration and functional recovery, research has focused on the construction and design of nerve conduction channels or guide tubes. That is why a high molecular weight chitosan was used as a starting material, which was first characterized by the following analyses: moisture, ash, FTIR, TGA, total nitrogen determination, viscosity for the determination of the average molecular weight and degree of deacetylation by potentiometric titration. Once the starting chitosan is characterized, tube-shaped biomaterials are prepared based on a 4% w/v chitosan solution, using CH3COOH solvent at 1% v/v. Calcium glutamate is added to 0.5% and 1% w/v, neutralizing with NaOH 0.25N, and then taken to the molds to be frozen and subsequently freeze-dried. Finally, the materials are coated with polylactic acid, in order to achieve a strengthening in the structure of the material. These materials are also prepared in a bio clean area. The different materials are chemically and morphologically characterized by FTIR, TGA, Atomic Absorption Spectroscopy, Mechanical Properties, Morphology and solubility test.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.3 20202020-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304870en10.4067/s0717-97072020000204870
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Neuronal tubes chitosan calcium glutamate polylactic acid freeze- dried
spellingShingle	Neuronal tubes chitosan calcium glutamate polylactic acid freeze- dried Cárdenas-Triviño,Galo Soto-Seguel,Rodrigo CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR
description	ABSTRACT Nerve regeneration is a biologically complex phenomenon. Once the nervous system is damaged, its recovery is difficult and causes a malfunction in other parts of the body that can occur because mature neurons do not suffer cell division. To increase the prospects of axonal regeneration and functional recovery, research has focused on the construction and design of nerve conduction channels or guide tubes. That is why a high molecular weight chitosan was used as a starting material, which was first characterized by the following analyses: moisture, ash, FTIR, TGA, total nitrogen determination, viscosity for the determination of the average molecular weight and degree of deacetylation by potentiometric titration. Once the starting chitosan is characterized, tube-shaped biomaterials are prepared based on a 4% w/v chitosan solution, using CH3COOH solvent at 1% v/v. Calcium glutamate is added to 0.5% and 1% w/v, neutralizing with NaOH 0.25N, and then taken to the molds to be frozen and subsequently freeze-dried. Finally, the materials are coated with polylactic acid, in order to achieve a strengthening in the structure of the material. These materials are also prepared in a bio clean area. The different materials are chemically and morphologically characterized by FTIR, TGA, Atomic Absorption Spectroscopy, Mechanical Properties, Morphology and solubility test.
author	Cárdenas-Triviño,Galo Soto-Seguel,Rodrigo
author_facet	Cárdenas-Triviño,Galo Soto-Seguel,Rodrigo
author_sort	Cárdenas-Triviño,Galo
title	CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR
title_short	CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR
title_full	CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR
title_fullStr	CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR
title_full_unstemmed	CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR
title_sort	chitosan composites preparation and characterization of guide tubes for nerve repair
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304870
work_keys_str_mv	AT cardenastrivinogalo chitosancompositespreparationandcharacterizationofguidetubesfornerverepair AT sotoseguelrodrigo chitosancompositespreparationandcharacterizationofguidetubesfornerverepair
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CHITOSAN COMPOSITES PREPARATION AND CHARACTERIZATION OF GUIDE TUBES FOR NERVE REPAIR

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