EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY

ABSTRACT One of the most widely used pharmaceuticals of the antibiotic type is quinolones. Nalidixic acid belongs to this family of antibiotics and it is widely used in both human and veterinary medicine. The main objective of this work is to show the behavior of nalidixic acid in co-solvent mixture...

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Autores principales:	Muñoz,Carla, Palacio,Daniel A., Rivas,Bernabé L.
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Naldixic acid antibiotic solvent ultraviolet spectra
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304885
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spelling	oai:scielo:S0717-970720200003048852020-10-09EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPYMuñoz,CarlaPalacio,Daniel A.Rivas,Bernabé L. Naldixic acid antibiotic solvent ultraviolet spectra ABSTRACT One of the most widely used pharmaceuticals of the antibiotic type is quinolones. Nalidixic acid belongs to this family of antibiotics and it is widely used in both human and veterinary medicine. The main objective of this work is to show the behavior of nalidixic acid in co-solvent mixtures, in order to study soon the removal of this antibiotic in aqueous solutions or mixtures of water with solvents. The study was carried out by preparing a standard solution containing 25 mg of nalidixic acid in 50 mL in different solvent mixtures. Subsequently, 20 mg L-1 solutions were prepared using the same mixture of solvents (acetone: water, methanol: water and ethanol: water) to be scanned for wavelengths by UV-Vis spectroscopy. The spectra showed signal displacement in all the mixtures when there was an increase concerning to the water contents due to the interaction of the water with the acid group of the antibiotic. While in mixtures of methanol: water and ethanol: water solutions, there is a variation of the absorption band intensities. As a conclusion, it can be said that it is important to consider the solubility capacity of this antibiotic in different solvents for the purposes of removal studies of this type of emerging contaminants of the antibiotic type.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.3 20202020-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304885en10.4067/s0717-97072020000204885
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Naldixic acid antibiotic solvent ultraviolet spectra
spellingShingle	Naldixic acid antibiotic solvent ultraviolet spectra Muñoz,Carla Palacio,Daniel A. Rivas,Bernabé L. EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY
description	ABSTRACT One of the most widely used pharmaceuticals of the antibiotic type is quinolones. Nalidixic acid belongs to this family of antibiotics and it is widely used in both human and veterinary medicine. The main objective of this work is to show the behavior of nalidixic acid in co-solvent mixtures, in order to study soon the removal of this antibiotic in aqueous solutions or mixtures of water with solvents. The study was carried out by preparing a standard solution containing 25 mg of nalidixic acid in 50 mL in different solvent mixtures. Subsequently, 20 mg L-1 solutions were prepared using the same mixture of solvents (acetone: water, methanol: water and ethanol: water) to be scanned for wavelengths by UV-Vis spectroscopy. The spectra showed signal displacement in all the mixtures when there was an increase concerning to the water contents due to the interaction of the water with the acid group of the antibiotic. While in mixtures of methanol: water and ethanol: water solutions, there is a variation of the absorption band intensities. As a conclusion, it can be said that it is important to consider the solubility capacity of this antibiotic in different solvents for the purposes of removal studies of this type of emerging contaminants of the antibiotic type.
author	Muñoz,Carla Palacio,Daniel A. Rivas,Bernabé L.
author_facet	Muñoz,Carla Palacio,Daniel A. Rivas,Bernabé L.
author_sort	Muñoz,Carla
title	EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY
title_short	EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY
title_full	EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY
title_fullStr	EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY
title_full_unstemmed	EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY
title_sort	effect of solvent behavior of nalidixic acid by ultraviolet spectroscopy
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304885
work_keys_str_mv	AT munozcarla effectofsolventbehaviorofnalidixicacidbyultravioletspectroscopy AT palaciodaniela effectofsolventbehaviorofnalidixicacidbyultravioletspectroscopy AT rivasbernabel effectofsolventbehaviorofnalidixicacidbyultravioletspectroscopy
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EFFECT OF SOLVENT BEHAVIOR OF NALIDIXIC ACID BY ULTRAVIOLET SPECTROSCOPY

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