DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

ABSTRACT Simple, fast, and sensitive spectrophotometric method was developed for the determination of metformin in pharmaceutical formulations. The spectrophotometric procedure was based on the oxidation of metformin with potassium permanganate in alkaline medium. The developed method was also valid...

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Autores principales:	Judeh,Ahmed Abu, Sarief,Abdulla, Umar,Yunusa, Ashwaq,Omar, Haque,Sk Manirul
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Spectrophotometer Metformin Method development Validation Tablets Computational
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304895
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spelling	oai:scielo:S0717-970720200003048952020-10-09DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONSJudeh,Ahmed AbuSarief,AbdullaUmar,YunusaAshwaq,OmarHaque,Sk Manirul Spectrophotometer Metformin Method development Validation Tablets Computational ABSTRACT Simple, fast, and sensitive spectrophotometric method was developed for the determination of metformin in pharmaceutical formulations. The spectrophotometric procedure was based on the oxidation of metformin with potassium permanganate in alkaline medium. The developed method was also validated according to International Conference on Harmonization guidelines parameters such as linearity, accuracy, precision, limit of detection and quantitation. Studies were conducted to investigate different parameters involved in color developments and optimized. The pure drug of metformin was extracted from a pharmaceutical dosage form. The extraction procedure was developed, and a possible reaction mechanism proposed in the manuscript. The IR spectrum of the extracted metformin was taken and compared with the simulated IR spectrum obtained from the density functional theory calculation. The vibrational assignment of the modes was done based on potential energy distribution.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.3 20202020-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304895en10.4067/s0717-97072020000204895
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Spectrophotometer Metformin Method development Validation Tablets Computational
spellingShingle	Spectrophotometer Metformin Method development Validation Tablets Computational Judeh,Ahmed Abu Sarief,Abdulla Umar,Yunusa Ashwaq,Omar Haque,Sk Manirul DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
description	ABSTRACT Simple, fast, and sensitive spectrophotometric method was developed for the determination of metformin in pharmaceutical formulations. The spectrophotometric procedure was based on the oxidation of metformin with potassium permanganate in alkaline medium. The developed method was also validated according to International Conference on Harmonization guidelines parameters such as linearity, accuracy, precision, limit of detection and quantitation. Studies were conducted to investigate different parameters involved in color developments and optimized. The pure drug of metformin was extracted from a pharmaceutical dosage form. The extraction procedure was developed, and a possible reaction mechanism proposed in the manuscript. The IR spectrum of the extracted metformin was taken and compared with the simulated IR spectrum obtained from the density functional theory calculation. The vibrational assignment of the modes was done based on potential energy distribution.
author	Judeh,Ahmed Abu Sarief,Abdulla Umar,Yunusa Ashwaq,Omar Haque,Sk Manirul
author_facet	Judeh,Ahmed Abu Sarief,Abdulla Umar,Yunusa Ashwaq,Omar Haque,Sk Manirul
author_sort	Judeh,Ahmed Abu
title	DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
title_short	DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
title_full	DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
title_fullStr	DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
title_full_unstemmed	DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS
title_sort	development, computational studies and validation of spectrophotometric method of metformin hydrochloride in pharmaceutical formulations
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304895
work_keys_str_mv	AT judehahmedabu developmentcomputationalstudiesandvalidationofspectrophotometricmethodofmetforminhydrochlorideinpharmaceuticalformulations AT sariefabdulla developmentcomputationalstudiesandvalidationofspectrophotometricmethodofmetforminhydrochlorideinpharmaceuticalformulations AT umaryunusa developmentcomputationalstudiesandvalidationofspectrophotometricmethodofmetforminhydrochlorideinpharmaceuticalformulations AT ashwaqomar developmentcomputationalstudiesandvalidationofspectrophotometricmethodofmetforminhydrochlorideinpharmaceuticalformulations AT haqueskmanirul developmentcomputationalstudiesandvalidationofspectrophotometricmethodofmetforminhydrochlorideinpharmaceuticalformulations
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DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

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