INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW

ABSTRACT Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively attached to produce novel drugs. Among various heterocyclic compounds, nitrogen-based heterocycles have been extensively investigated as they constitute the core structures of numerous biologically rel...

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Autores principales:	Sachdeva,Harshita, Mathur,Jaya, Guleria,Anjali
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Heterocyclic compounds Nitrogen-based Indole Spiro-indole Anticancer agents
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304900
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spelling	oai:scielo:S0717-970720200003049002020-10-09INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEWSachdeva,HarshitaMathur,JayaGuleria,Anjali Heterocyclic compounds Nitrogen-based Indole Spiro-indole Anticancer agents ABSTRACT Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively attached to produce novel drugs. Among various heterocyclic compounds, nitrogen-based heterocycles have been extensively investigated as they constitute the core structures of numerous biologically relevant molecules and have been found to be active against different types of cancers. Due to the versatility of indole, it has been a highly “privileged motif” for the target-based design and development of anticancer agents. Moreover, it has been used as a synthon for the preparation of large number of bioactive heterocycles and paved a way to develop effective targets. This review article presents comprehensive overview of anticancer potentiality of diversely substituted indole derivatives including 1H-indole-2,3-dione and Spiro indole derivatives.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.3 20202020-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304900en10.4067/s0717-97072020000204900
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Heterocyclic compounds Nitrogen-based Indole Spiro-indole Anticancer agents
spellingShingle	Heterocyclic compounds Nitrogen-based Indole Spiro-indole Anticancer agents Sachdeva,Harshita Mathur,Jaya Guleria,Anjali INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW
description	ABSTRACT Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively attached to produce novel drugs. Among various heterocyclic compounds, nitrogen-based heterocycles have been extensively investigated as they constitute the core structures of numerous biologically relevant molecules and have been found to be active against different types of cancers. Due to the versatility of indole, it has been a highly “privileged motif” for the target-based design and development of anticancer agents. Moreover, it has been used as a synthon for the preparation of large number of bioactive heterocycles and paved a way to develop effective targets. This review article presents comprehensive overview of anticancer potentiality of diversely substituted indole derivatives including 1H-indole-2,3-dione and Spiro indole derivatives.
author	Sachdeva,Harshita Mathur,Jaya Guleria,Anjali
author_facet	Sachdeva,Harshita Mathur,Jaya Guleria,Anjali
author_sort	Sachdeva,Harshita
title	INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW
title_short	INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW
title_full	INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW
title_fullStr	INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW
title_full_unstemmed	INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW
title_sort	indole derivatives as potential anticancer agents: a review
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304900
work_keys_str_mv	AT sachdevaharshita indolederivativesaspotentialanticanceragentsareview AT mathurjaya indolederivativesaspotentialanticanceragentsareview AT guleriaanjali indolederivativesaspotentialanticanceragentsareview
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INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW

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