CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY

ABSTRACT A new chromium (III) coordination compound of 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene (ACTT) (3) with Cr(NO3)3.9H2O in methanol at room temperature for 48 hours has been prepared. The composition of the new complex compound (4) has been confirmed by a number of instrument...

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Autores principales:	Siéwé,Désire André, Fondjo,Emmanuel Sopbué, Tamokou,Jean-de-Dieu, Ekom,Steve Endeguele, Dimo,Kamal Sorel Djeukoua, Doungmo,Giscard, Walters,Mallory E., Tsopmo,Appolinnaire, Simon,Peter F. W., Kuiate,Jules-Roger
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2020
Materias:	Antimicrobial Complexation reaction 4,5,6,7-tetrahydrobenzo[b]- thiophene Chromium complex
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304908
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spelling	oai:scielo:S0717-970720200003049082020-10-09CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITYSiéwé,Désire AndréFondjo,Emmanuel SopbuéTamokou,Jean-de-DieuEkom,Steve EndegueleDimo,Kamal Sorel DjeukouaDoungmo,GiscardWalters,Mallory E.Tsopmo,AppolinnaireSimon,Peter F. W.Kuiate,Jules-Roger Antimicrobial Complexation reaction 4,5,6,7-tetrahydrobenzo[b]- thiophene Chromium complex ABSTRACT A new chromium (III) coordination compound of 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene (ACTT) (3) with Cr(NO3)3.9H2O in methanol at room temperature for 48 hours has been prepared. The composition of the new complex compound (4) has been confirmed by a number of instrumental methods including IR, NMR, MS and elemental analysis. It was found that the ACTT ligand behaves as bidentate chelating agent and coordinates to the central metal ion through the nitrogen atom of the amino-group and the oxygen atom of the carbonyl function of the ester group. The results showed that in the coordination sphere of the complex, the metal ion is coordinated by three chelating ACTT ligands. In the structure of the cation core [Cr(ACTT)3]3+, the three ACTT ligands are linked to the chromium ion through three Cr-N and three Cr-O bonds forming a square bipyramidal geometry. The metal complex and the ACTT ligand were screened for their antimicrobial activities against several strains of bacteria (Staphylococcus aureus ATCC25923, Escherichia coli S2 (1), Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa ATCC27853, Shigella flexneri SDINT) and fungi (Candida albicans ATCC10231, Candida tropicalis PK233, Cryptococcus neoformans H99). The chromium complex showed promising antimicrobial activity against the microorganisms with minimum inhibitory values between 4 and 16 μg/mL.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.65 n.3 20202020-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304908en10.4067/s0717-97072020000204908
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Antimicrobial Complexation reaction 4,5,6,7-tetrahydrobenzo[b]- thiophene Chromium complex
spellingShingle	Antimicrobial Complexation reaction 4,5,6,7-tetrahydrobenzo[b]- thiophene Chromium complex Siéwé,Désire André Fondjo,Emmanuel Sopbué Tamokou,Jean-de-Dieu Ekom,Steve Endeguele Dimo,Kamal Sorel Djeukoua Doungmo,Giscard Walters,Mallory E. Tsopmo,Appolinnaire Simon,Peter F. W. Kuiate,Jules-Roger CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
description	ABSTRACT A new chromium (III) coordination compound of 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene (ACTT) (3) with Cr(NO3)3.9H2O in methanol at room temperature for 48 hours has been prepared. The composition of the new complex compound (4) has been confirmed by a number of instrumental methods including IR, NMR, MS and elemental analysis. It was found that the ACTT ligand behaves as bidentate chelating agent and coordinates to the central metal ion through the nitrogen atom of the amino-group and the oxygen atom of the carbonyl function of the ester group. The results showed that in the coordination sphere of the complex, the metal ion is coordinated by three chelating ACTT ligands. In the structure of the cation core [Cr(ACTT)3]3+, the three ACTT ligands are linked to the chromium ion through three Cr-N and three Cr-O bonds forming a square bipyramidal geometry. The metal complex and the ACTT ligand were screened for their antimicrobial activities against several strains of bacteria (Staphylococcus aureus ATCC25923, Escherichia coli S2 (1), Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa ATCC27853, Shigella flexneri SDINT) and fungi (Candida albicans ATCC10231, Candida tropicalis PK233, Cryptococcus neoformans H99). The chromium complex showed promising antimicrobial activity against the microorganisms with minimum inhibitory values between 4 and 16 μg/mL.
author	Siéwé,Désire André Fondjo,Emmanuel Sopbué Tamokou,Jean-de-Dieu Ekom,Steve Endeguele Dimo,Kamal Sorel Djeukoua Doungmo,Giscard Walters,Mallory E. Tsopmo,Appolinnaire Simon,Peter F. W. Kuiate,Jules-Roger
author_facet	Siéwé,Désire André Fondjo,Emmanuel Sopbué Tamokou,Jean-de-Dieu Ekom,Steve Endeguele Dimo,Kamal Sorel Djeukoua Doungmo,Giscard Walters,Mallory E. Tsopmo,Appolinnaire Simon,Peter F. W. Kuiate,Jules-Roger
author_sort	Siéwé,Désire André
title	CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
title_short	CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
title_full	CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
title_fullStr	CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
title_full_unstemmed	CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY
title_sort	chromium (iii) complex of 2-amino-3-carbomethoxy-4,5,6,7-tetrahydrobenzo[b] thiophene: synthesis, characterization and antimicrobial activity
publisher	Sociedad Chilena de Química
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072020000304908
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CHROMIUM (III) COMPLEX OF 2-AMINO-3-CARBOMETHOXY-4,5,6,7-TETRAHYDROBENZO[B] THIOPHENE: SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY

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