PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense

ABSTRACT Phytochemical profile of the Central American rainforest endemic Annonaceae species, Annona pittieri and Cymbonopetallum costaricense, were studied in search of novel bioactive compounds. The acetogenin squamocin (1) isolated from A. pittieri showed cytotoxic activity against human acute ly...

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Autores principales:	Parra,Jonathan, Ford,Christian De, Murillo,Renato
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2021
Materias:	Alkaloids Annonaceae Annona pittieri Cymbopetalum costaricense squamocin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105047
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spelling	oai:scielo:S0717-970720210001050472021-04-22PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricenseParra,JonathanFord,Christian DeMurillo,Renato Alkaloids Annonaceae Annona pittieri Cymbopetalum costaricense squamocin ABSTRACT Phytochemical profile of the Central American rainforest endemic Annonaceae species, Annona pittieri and Cymbonopetallum costaricense, were studied in search of novel bioactive compounds. The acetogenin squamocin (1) isolated from A. pittieri showed cytotoxic activity against human acute lymphocytic leukaemia with low activity against healthy blood cells. In addition, other eight compounds were isolated from A. pittieri, including a novel 2-azaanthraquinone alkaloid, 4-methoxybenzo[g]isoquinoline-5,10-dione (2). Furthermore, from C. costaricense three compounds were isolated including a novel 1-azaanthraquinone alkaloid, 6-hydroxy-9-methoxy-cleistopholine (3).info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.66 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105047en10.4067/S0717-97072021000105047
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Alkaloids Annonaceae Annona pittieri Cymbopetalum costaricense squamocin
spellingShingle	Alkaloids Annonaceae Annona pittieri Cymbopetalum costaricense squamocin Parra,Jonathan Ford,Christian De Murillo,Renato PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense
description	ABSTRACT Phytochemical profile of the Central American rainforest endemic Annonaceae species, Annona pittieri and Cymbonopetallum costaricense, were studied in search of novel bioactive compounds. The acetogenin squamocin (1) isolated from A. pittieri showed cytotoxic activity against human acute lymphocytic leukaemia with low activity against healthy blood cells. In addition, other eight compounds were isolated from A. pittieri, including a novel 2-azaanthraquinone alkaloid, 4-methoxybenzo[g]isoquinoline-5,10-dione (2). Furthermore, from C. costaricense three compounds were isolated including a novel 1-azaanthraquinone alkaloid, 6-hydroxy-9-methoxy-cleistopholine (3).
author	Parra,Jonathan Ford,Christian De Murillo,Renato
author_facet	Parra,Jonathan Ford,Christian De Murillo,Renato
author_sort	Parra,Jonathan
title	PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense
title_short	PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense
title_full	PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense
title_fullStr	PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense
title_full_unstemmed	PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense
title_sort	phytochemical study of endemic costa rican annonaceae species annona pittieri and cymbopetalum costaricense
publisher	Sociedad Chilena de Química
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105047
work_keys_str_mv	AT parrajonathan phytochemicalstudyofendemiccostaricanannonaceaespeciesannonapittieriandcymbopetalumcostaricense AT fordchristiande phytochemicalstudyofendemiccostaricanannonaceaespeciesannonapittieriandcymbopetalumcostaricense AT murillorenato phytochemicalstudyofendemiccostaricanannonaceaespeciesannonapittieriandcymbopetalumcostaricense
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PHYTOCHEMICAL STUDY OF ENDEMIC COSTA RICAN ANNONACEAE SPECIES Annona pittieri AND Cymbopetalum costaricense

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