IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS

ABSTRACT By condensing ethylene-1,2-diamine with different aldehydes such as benzaldehyde, 4-chloroacetophenone and 2-chlorobenzaldeyhde within 1:2 molar ratio, resulted new series of Schiff base ligands (L1)-(L3) containing bidentate nitrogen atom. Their metal complexes were synthesized by coordina...

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Autores principales:	Hussain Sumrra,Sajjad, Imran,Muhammad, Ibrahim,Muhammad, Ambreen,Sabahat, Mehmood,Rashad, Assiri,Mohammed Abdullah, Irfan,Ahmad
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2021
Materias:	Bidentate Schiff bases Metal(II) Complexes Antibacterial Antifungal MIC Activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105057
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spelling	oai:scielo:S0717-970720210001050572021-04-22IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDSHussain Sumrra,SajjadImran,MuhammadIbrahim,MuhammadAmbreen,SabahatMehmood,RashadAssiri,Mohammed AbdullahIrfan,Ahmad Bidentate Schiff bases Metal(II) Complexes Antibacterial Antifungal MIC Activity ABSTRACT By condensing ethylene-1,2-diamine with different aldehydes such as benzaldehyde, 4-chloroacetophenone and 2-chlorobenzaldeyhde within 1:2 molar ratio, resulted new series of Schiff base ligands (L1)-(L3) containing bidentate nitrogen atom. Their metal complexes were synthesized by coordinating the ligands with transition metals as Co(II), Cu(II), Ni(II) and Zn(II) and exhibited octahedral geometry. Their characterization was done with the help of spectral, physical and analytical analysis. Spectral and elemental analysis of all bidentate ligands and their corresponding 3d-metal chelates was consistent with their proposed structures, signifying the high purity of these compounds. For in-vitro studies, these metal complexes along their ligands were screened against the six bacterial strains; Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus and Streptococcus faecalis. Six fungal strains; Aspergillus niger, Trichophyton mentogrophytes, Epidermophyton floccosum, Trichophyton schoenleinii, Microscopum canis and Fusarium culmorum were used to study antifungal activity of the compounds. Bioactivity results exhibited that metal complexes showed higher antimicrobial potential as compared with their corresponding ligands. The enhanced activity resulted due to chelation that decreases the polarity of metal ions by complexing with bidentate ligands.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.66 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105057en10.4067/S0717-97072021000105057
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Bidentate Schiff bases Metal(II) Complexes Antibacterial Antifungal MIC Activity
spellingShingle	Bidentate Schiff bases Metal(II) Complexes Antibacterial Antifungal MIC Activity Hussain Sumrra,Sajjad Imran,Muhammad Ibrahim,Muhammad Ambreen,Sabahat Mehmood,Rashad Assiri,Mohammed Abdullah Irfan,Ahmad IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS
description	ABSTRACT By condensing ethylene-1,2-diamine with different aldehydes such as benzaldehyde, 4-chloroacetophenone and 2-chlorobenzaldeyhde within 1:2 molar ratio, resulted new series of Schiff base ligands (L1)-(L3) containing bidentate nitrogen atom. Their metal complexes were synthesized by coordinating the ligands with transition metals as Co(II), Cu(II), Ni(II) and Zn(II) and exhibited octahedral geometry. Their characterization was done with the help of spectral, physical and analytical analysis. Spectral and elemental analysis of all bidentate ligands and their corresponding 3d-metal chelates was consistent with their proposed structures, signifying the high purity of these compounds. For in-vitro studies, these metal complexes along their ligands were screened against the six bacterial strains; Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus and Streptococcus faecalis. Six fungal strains; Aspergillus niger, Trichophyton mentogrophytes, Epidermophyton floccosum, Trichophyton schoenleinii, Microscopum canis and Fusarium culmorum were used to study antifungal activity of the compounds. Bioactivity results exhibited that metal complexes showed higher antimicrobial potential as compared with their corresponding ligands. The enhanced activity resulted due to chelation that decreases the polarity of metal ions by complexing with bidentate ligands.
author	Hussain Sumrra,Sajjad Imran,Muhammad Ibrahim,Muhammad Ambreen,Sabahat Mehmood,Rashad Assiri,Mohammed Abdullah Irfan,Ahmad
author_facet	Hussain Sumrra,Sajjad Imran,Muhammad Ibrahim,Muhammad Ambreen,Sabahat Mehmood,Rashad Assiri,Mohammed Abdullah Irfan,Ahmad
author_sort	Hussain Sumrra,Sajjad
title	IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS
title_short	IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS
title_full	IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS
title_fullStr	IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS
title_full_unstemmed	IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS
title_sort	in-vitro antimicrobial screening and coordination behavior of metals based bidentate compounds
publisher	Sociedad Chilena de Química
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105057
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IN-VITRO ANTIMICROBIAL SCREENING AND COORDINATION BEHAVIOR OF METALS BASED BIDENTATE COMPOUNDS

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