SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE

SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE

ABSTRACT A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has bett...

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Autores principales: Ramirez-Tagle,Rodrigo, Salgado-Moran,Guillermo, Mendez-Luna,David, Correa-Basurto,José, Villada,Wilson Cardona, Candia,Lorena Gerli, Mendoza-Huizar,Luis H.
Lenguaje:English
Publicado: Sociedad Chilena de Química 2021
Materias:
Amlodipine
Chitosan
Nanocomposite
Drug-release properties
Docking studies
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105063
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spelling oai:scielo:S0717-970720210001050632021-04-22SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITERamirez-Tagle,RodrigoSalgado-Moran,GuillermoMendez-Luna,DavidCorrea-Basurto,JoséVillada,Wilson CardonaCandia,Lorena GerliMendoza-Huizar,Luis H. Amlodipine Chitosan Nanocomposite Drug-release properties Docking studies ABSTRACT A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.66 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105063en10.4067/S0717-97072021000105063
institution Scielo Chile
collection Scielo Chile
language English
topic Amlodipine
Chitosan
Nanocomposite
Drug-release properties
Docking studies
spellingShingle Amlodipine
Chitosan
Nanocomposite
Drug-release properties
Docking studies
Ramirez-Tagle,Rodrigo
Salgado-Moran,Guillermo
Mendez-Luna,David
Correa-Basurto,José
Villada,Wilson Cardona
Candia,Lorena Gerli
Mendoza-Huizar,Luis H.
SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE
description ABSTRACT A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.
author Ramirez-Tagle,Rodrigo
Salgado-Moran,Guillermo
Mendez-Luna,David
Correa-Basurto,José
Villada,Wilson Cardona
Candia,Lorena Gerli
Mendoza-Huizar,Luis H.
author_facet Ramirez-Tagle,Rodrigo
Salgado-Moran,Guillermo
Mendez-Luna,David
Correa-Basurto,José
Villada,Wilson Cardona
Candia,Lorena Gerli
Mendoza-Huizar,Luis H.
author_sort Ramirez-Tagle,Rodrigo
title SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE
title_short SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE
title_full SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE
title_fullStr SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE
title_full_unstemmed SYNTHESIS, CHEMICAL IDENTIFICATION, DRUG RELEASE AND DOCKING STUDIES OF THE AMLODIPINE–CHITOSAN NANOBIOPOLYMER COMPOSITE
title_sort synthesis, chemical identification, drug release and docking studies of the amlodipine–chitosan nanobiopolymer composite
publisher Sociedad Chilena de Química
publishDate 2021
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105063
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