PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN

ABSTRACT This investigation aimed to evaluate the phytochemical constituents, antioxidant, antibacterial and α-glucosidase inhibitory activities of A. tomentosa essential oil. The essential oil extracted using steam distillation method possessed antibacterial activity for all tested bacteri...

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Autores principales:	Alsohaili,Sohail Ahmad, Sulaiman,Shaida Fariza
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2021
Materias:	Achillea tomentosa Antioxidant α-glucosidase inhibitory Antibacterial DPPH assay FRAP assay
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105093
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spelling	oai:scielo:S0717-970720210001050932021-04-22PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDANAlsohaili,Sohail AhmadSulaiman,Shaida Fariza Achillea tomentosa Antioxidant α-glucosidase inhibitory Antibacterial DPPH assay FRAP assay ABSTRACT This investigation aimed to evaluate the phytochemical constituents, antioxidant, antibacterial and α-glucosidase inhibitory activities of A. tomentosa essential oil. The essential oil extracted using steam distillation method possessed antibacterial activity for all tested bacteria. Comparing to cefaclor the percentage of relative inhibition zone diameter (RIZD) was 100.30 ± 4.73 % for Staphylococcus aureus and ranged between 79.67 ± 3.79 % and 84.33 ± 4.16 % for other bacteria. The essential oil showed considerable antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, ferric reducing antioxidant power (FRAP) assay and metal chelating methods, the EC50 of the essential oil were 72.06 ± 3.99, 54.69 ± 4.69 and 50.39 ± 2.86 µg/ml respectively, comparing 7.34 ± 2.43, 10.87 ± 3.34 and 14.50 ± 3.46 µg/ml for positive controls (Trolox, EDTA and Quercetin respectively). The essential oil also possessed concentration dependent α-glucosidase inhibitory activity with EC50 149.20 ± 7.63 µg/ml comparing to acarabose EC50 14.50 ± 3.46 µg/ml. Forty compounds were identified depending in retention index (RI) and mass spectra (MS) that form 96.31 % of the essential oil composition. The result showed that the ratio of the identified compounds range between 0.11 % and 23.72 %, 3-Carene (23.72 %), Limonene (12.19 %) and α-Terpinyl acetate (10.22%) were found to be the major components of the essential oil. m-Cyneme (7.11 %) and Di-n-octyl phthalate (4.50 %) present in moderate quantities. The phytochemical analyzes showed that the identified compound quantitatively and qualitatively differ from the previous study that investigate the composition of A.tomentosa L. essential oil.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.66 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105093en10.4067/S0717-97072021000105093
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Achillea tomentosa Antioxidant α-glucosidase inhibitory Antibacterial DPPH assay FRAP assay
spellingShingle	Achillea tomentosa Antioxidant α-glucosidase inhibitory Antibacterial DPPH assay FRAP assay Alsohaili,Sohail Ahmad Sulaiman,Shaida Fariza PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN
description	ABSTRACT This investigation aimed to evaluate the phytochemical constituents, antioxidant, antibacterial and α-glucosidase inhibitory activities of A. tomentosa essential oil. The essential oil extracted using steam distillation method possessed antibacterial activity for all tested bacteria. Comparing to cefaclor the percentage of relative inhibition zone diameter (RIZD) was 100.30 ± 4.73 % for Staphylococcus aureus and ranged between 79.67 ± 3.79 % and 84.33 ± 4.16 % for other bacteria. The essential oil showed considerable antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, ferric reducing antioxidant power (FRAP) assay and metal chelating methods, the EC50 of the essential oil were 72.06 ± 3.99, 54.69 ± 4.69 and 50.39 ± 2.86 µg/ml respectively, comparing 7.34 ± 2.43, 10.87 ± 3.34 and 14.50 ± 3.46 µg/ml for positive controls (Trolox, EDTA and Quercetin respectively). The essential oil also possessed concentration dependent α-glucosidase inhibitory activity with EC50 149.20 ± 7.63 µg/ml comparing to acarabose EC50 14.50 ± 3.46 µg/ml. Forty compounds were identified depending in retention index (RI) and mass spectra (MS) that form 96.31 % of the essential oil composition. The result showed that the ratio of the identified compounds range between 0.11 % and 23.72 %, 3-Carene (23.72 %), Limonene (12.19 %) and α-Terpinyl acetate (10.22%) were found to be the major components of the essential oil. m-Cyneme (7.11 %) and Di-n-octyl phthalate (4.50 %) present in moderate quantities. The phytochemical analyzes showed that the identified compound quantitatively and qualitatively differ from the previous study that investigate the composition of A.tomentosa L. essential oil.
author	Alsohaili,Sohail Ahmad Sulaiman,Shaida Fariza
author_facet	Alsohaili,Sohail Ahmad Sulaiman,Shaida Fariza
author_sort	Alsohaili,Sohail Ahmad
title	PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN
title_short	PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN
title_full	PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN
title_fullStr	PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN
title_full_unstemmed	PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN
title_sort	phytochemical constituents, antioxidant, antibacterial and enzyme inhibition activities of essential oil from the aerial part of achillea tomentosa l. grown in jordan
publisher	Sociedad Chilena de Química
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000105093
work_keys_str_mv	AT alsohailisohailahmad phytochemicalconstituentsantioxidantantibacterialandenzymeinhibitionactivitiesofessentialoilfromtheaerialpartofachilleatomentosalgrowninjordan AT sulaimanshaidafariza phytochemicalconstituentsantioxidantantibacterialandenzymeinhibitionactivitiesofessentialoilfromtheaerialpartofachilleatomentosalgrowninjordan
_version_	1714200956235677696

PHYTOCHEMICAL CONSTITUENTS, ANTIOXIDANT, ANTIBACTERIAL AND ENZYME INHIBITION ACTIVITIES OF ESSENTIAL OIL FROM THE AERIAL PART OF Achillea tomentosa L. GROWN IN JORDAN

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