ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES
ABSTRACT The synthesized N,N′ -bis(ferrocenylmethylene)ethylenediamine Schiff base and it’s metal complexes were screened in vitro for antimicrobial activity against two Gram-positive ( Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative ( Escherichia...
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Sociedad Chilena de Química
2021
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oai:scielo:S0717-970720210003052372021-10-14ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXESÖzbek,Hülya AvciÇinar,SedaOskay,MustafaAydemİr,TülİnDemİrhan,Funda Antimicrobial activity Ferrocene Schiff base Schiff base metal complex SOD-like activity ABSTRACT The synthesized N,N′ -bis(ferrocenylmethylene)ethylenediamine Schiff base and it’s metal complexes were screened in vitro for antimicrobial activity against two Gram-positive ( Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative ( Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048, Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans . MIC values of the compounds ranged from 27 to 533 μg/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 μg/mL). The lowest MIC for C. albicans was obtained 107 μg/mL. The superoxide dismutase activity of Schiff base and it’s metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 μm IC50) activity, the SOD-like activity value was not determined in the other complex and ligand.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.66 n.3 20212021-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000305237en10.4067/S0717-97072021000305237 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Antimicrobial activity Ferrocene Schiff base Schiff base metal complex SOD-like activity |
| spellingShingle |
Antimicrobial activity Ferrocene Schiff base Schiff base metal complex SOD-like activity Özbek,Hülya Avci Çinar,Seda Oskay,Mustafa Aydemİr,Tülİn Demİrhan,Funda ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES |
| description |
ABSTRACT The synthesized N,N′ -bis(ferrocenylmethylene)ethylenediamine Schiff base and it’s metal complexes were screened in vitro for antimicrobial activity against two Gram-positive ( Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064), four Gram-negative ( Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048, Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans . MIC values of the compounds ranged from 27 to 533 μg/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 μg/mL). The lowest MIC for C. albicans was obtained 107 μg/mL. The superoxide dismutase activity of Schiff base and it’s metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 μm IC50) activity, the SOD-like activity value was not determined in the other complex and ligand. |
| author |
Özbek,Hülya Avci Çinar,Seda Oskay,Mustafa Aydemİr,Tülİn Demİrhan,Funda |
| author_facet |
Özbek,Hülya Avci Çinar,Seda Oskay,Mustafa Aydemİr,Tülİn Demİrhan,Funda |
| author_sort |
Özbek,Hülya Avci |
| title |
ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES |
| title_short |
ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES |
| title_full |
ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES |
| title_fullStr |
ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES |
| title_full_unstemmed |
ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′ -BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES |
| title_sort |
antimicrobial and sod-like activities of n,n′ -bis(ferrocenylmethylene)ethylenediamine schiff base and it’s metal complexes |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2021 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072021000305237 |
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