Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects

In horses, insulin resistance is associated with several comorbidities such as obesity, laminitis, colic and osteochondrosis. The multifactorial causes of insulin resistance in horses have been addressed, which include genetic and environmental factors. As a consequence of these factors, the cellula...

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Autores principales:	Gandarillas,Monica, Matus,José Tomás, Márquez-Hernández,Roberto I, Vargas-Bello-Pérez,Einar
Lenguaje:	English
Publicado:	Pontificia Universidad Católica de Chile. Facultad de Agronomía e Ingeniería Forestal 2015
Materias:	Equine nutrition insulin resistance PPAR-gamma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202015000200001
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spelling	oai:scielo:S0718-162020150002000012015-09-16Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspectsGandarillas,MonicaMatus,José TomásMárquez-Hernández,Roberto IVargas-Bello-Pérez,Einar Equine nutrition insulin resistance PPAR-gamma In horses, insulin resistance is associated with several comorbidities such as obesity, laminitis, colic and osteochondrosis. The multifactorial causes of insulin resistance in horses have been addressed, which include genetic and environmental factors. As a consequence of these factors, the cellular signaling pathways responsible for insulin synthesis, the glucose intake in target cells of peripheral tissues and other related processes (e.g., adipocytokine signaling pathways) are affected. In response to insulin, changes in gene expression occur, which are required for the integration of an entire network of metabolic and physiological responses in different organs. The peroxisome proliferator-activated receptors (PPARs) were the particular focus of studies in recent years, mostly in humans. The PPARs are the primary transcriptional regulators of adipocyte differentiation and lipid metabolism. They have a direct effect on the expression of the genes involved in glucid homeostasis and were recently associated with type-2 diabetes. A molecular framework to define the insulin-related pathologies has not been developed for horses. Additionally, the establishment of a proper diagnosis of insulin resistance is fundamental in this species. The aims of this review were to discuss the etiology to identify the primary causes of insulin resistance and to examine the current progress in understanding this pathology in horses. Future research should study how nutrients modulate the expression of genes related to energy metabolism under the physiopathological condition of insulin resistance.info:eu-repo/semantics/openAccessPontificia Universidad Católica de Chile. Facultad de Agronomía e Ingeniería ForestalCiencia e investigación agraria v.42 n.2 20152015-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202015000200001en10.4067/S0718-16202015000200001
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Equine nutrition insulin resistance PPAR-gamma
spellingShingle	Equine nutrition insulin resistance PPAR-gamma Gandarillas,Monica Matus,José Tomás Márquez-Hernández,Roberto I Vargas-Bello-Pérez,Einar Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects
description	In horses, insulin resistance is associated with several comorbidities such as obesity, laminitis, colic and osteochondrosis. The multifactorial causes of insulin resistance in horses have been addressed, which include genetic and environmental factors. As a consequence of these factors, the cellular signaling pathways responsible for insulin synthesis, the glucose intake in target cells of peripheral tissues and other related processes (e.g., adipocytokine signaling pathways) are affected. In response to insulin, changes in gene expression occur, which are required for the integration of an entire network of metabolic and physiological responses in different organs. The peroxisome proliferator-activated receptors (PPARs) were the particular focus of studies in recent years, mostly in humans. The PPARs are the primary transcriptional regulators of adipocyte differentiation and lipid metabolism. They have a direct effect on the expression of the genes involved in glucid homeostasis and were recently associated with type-2 diabetes. A molecular framework to define the insulin-related pathologies has not been developed for horses. Additionally, the establishment of a proper diagnosis of insulin resistance is fundamental in this species. The aims of this review were to discuss the etiology to identify the primary causes of insulin resistance and to examine the current progress in understanding this pathology in horses. Future research should study how nutrients modulate the expression of genes related to energy metabolism under the physiopathological condition of insulin resistance.
author	Gandarillas,Monica Matus,José Tomás Márquez-Hernández,Roberto I Vargas-Bello-Pérez,Einar
author_facet	Gandarillas,Monica Matus,José Tomás Márquez-Hernández,Roberto I Vargas-Bello-Pérez,Einar
author_sort	Gandarillas,Monica
title	Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects
title_short	Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects
title_full	Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects
title_fullStr	Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects
title_full_unstemmed	Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects
title_sort	development of insulin resistance in horses (equus caballus): etiologic and molecular aspects
publisher	Pontificia Universidad Católica de Chile. Facultad de Agronomía e Ingeniería Forestal
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-16202015000200001
work_keys_str_mv	AT gandarillasmonica developmentofinsulinresistanceinhorsesequuscaballusetiologicandmolecularaspects AT matusjosetomas developmentofinsulinresistanceinhorsesequuscaballusetiologicandmolecularaspects AT marquezhernandezrobertoi developmentofinsulinresistanceinhorsesequuscaballusetiologicandmolecularaspects AT vargasbelloperezeinar developmentofinsulinresistanceinhorsesequuscaballusetiologicandmolecularaspects
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Development of insulin resistance in horses (Equus caballus): etiologic and molecular aspects

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