Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis

In the last decade, the interest for searching molecules with biomedical potential as well as innocuous for the environment has been increased. Under this perspective, the search for bioactive principles of marine origin has allowed to value the biological diversity present in aquatic systems. In ph...

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Autores principales:	Sottorff,Ignacio, Aballay,Ambbar, Hernández,Víctor, Roa,Luis, Muñoz,Lilian X, Silva,Mario, Becerra,José, Astuya,Allisson
Lenguaje:	English
Publicado:	Universidad de Valparaíso. Facultad de Ciencias del Mar 2013
Materias:	Holothuria holothurinoside D saponins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572013000100003
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spelling	oai:scielo:S0718-195720130001000032014-09-09Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensisSottorff,IgnacioAballay,AmbbarHernández,VíctorRoa,LuisMuñoz,Lilian XSilva,MarioBecerra,JoséAstuya,Allisson Holothuria holothurinoside D saponins In the last decade, the interest for searching molecules with biomedical potential as well as innocuous for the environment has been increased. Under this perspective, the search for bioactive principles of marine origin has allowed to value the biological diversity present in aquatic systems. In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of synthesizing molecules such as saponins and other secondary metabolites of high pharmacological interest because of their interesting haemolytic, antitumor, anti-inflammatory, antimicrobial, cytostatic and antineoplastic capacity. The aim of the present study was focused on the characterization of a purified extract obtained from Athyonidium chilensis (Holothuria) by chromatographic and mass spectrometric techniques and the later assessment of its bioactive potential on in vitro models. As a result of these analyses 2 saponins were identified. The first with a molecular weight of 1522 Da and highly conjugated with monosaccharides. The second with a molecular weight of 764 Da was identified as holothurinoside D. The biological activity of the purified extract showed antibacterial, antifungal and cytotoxic activity on a neuroblastoma cell line. Outcomes of this study correspond to the first characterization of molecules with biological activity from Athyonidium chilensis.info:eu-repo/semantics/openAccessUniversidad de Valparaíso. Facultad de Ciencias del MarRevista de biología marina y oceanografía v.48 n.1 20132013-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572013000100003en10.4067/S0718-19572013000100003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Holothuria holothurinoside D saponins
spellingShingle	Holothuria holothurinoside D saponins Sottorff,Ignacio Aballay,Ambbar Hernández,Víctor Roa,Luis Muñoz,Lilian X Silva,Mario Becerra,José Astuya,Allisson Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis
description	In the last decade, the interest for searching molecules with biomedical potential as well as innocuous for the environment has been increased. Under this perspective, the search for bioactive principles of marine origin has allowed to value the biological diversity present in aquatic systems. In phylum Echinodermata, the family Holothuridae is distinguished by its capacity of synthesizing molecules such as saponins and other secondary metabolites of high pharmacological interest because of their interesting haemolytic, antitumor, anti-inflammatory, antimicrobial, cytostatic and antineoplastic capacity. The aim of the present study was focused on the characterization of a purified extract obtained from Athyonidium chilensis (Holothuria) by chromatographic and mass spectrometric techniques and the later assessment of its bioactive potential on in vitro models. As a result of these analyses 2 saponins were identified. The first with a molecular weight of 1522 Da and highly conjugated with monosaccharides. The second with a molecular weight of 764 Da was identified as holothurinoside D. The biological activity of the purified extract showed antibacterial, antifungal and cytotoxic activity on a neuroblastoma cell line. Outcomes of this study correspond to the first characterization of molecules with biological activity from Athyonidium chilensis.
author	Sottorff,Ignacio Aballay,Ambbar Hernández,Víctor Roa,Luis Muñoz,Lilian X Silva,Mario Becerra,José Astuya,Allisson
author_facet	Sottorff,Ignacio Aballay,Ambbar Hernández,Víctor Roa,Luis Muñoz,Lilian X Silva,Mario Becerra,José Astuya,Allisson
author_sort	Sottorff,Ignacio
title	Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis
title_short	Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis
title_full	Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis
title_fullStr	Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis
title_full_unstemmed	Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis
title_sort	characterization of bioactive molecules isolated from sea cucumber athyonidium chilensis
publisher	Universidad de Valparaíso. Facultad de Ciencias del Mar
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572013000100003
work_keys_str_mv	AT sottorffignacio characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis AT aballayambbar characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis AT hernandezvictor characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis AT roaluis characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis AT munozlilianx characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis AT silvamario characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis AT becerrajose characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis AT astuyaallisson characterizationofbioactivemoleculesisolatedfromseacucumberathyonidiumchilensis
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Characterization of bioactive molecules isolated from sea cucumber Athyonidium chilensis

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