Compounds isolated from Salinispora arenicola of the Gulf of California, México

The marine actinobacterium AMS370, identified as Salinispora arenicola by 16S rRNA amplified gene comparison, was isolated from sediments of the Gulf of California, Mexico. From its semi-polar extract, 8 known compounds were isolated: 4-Hydroxy-phenyl acetic acid (1), 5-Methyl-2-methylene-2,3-dihydr...

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Autores principales:	Íñiguez-Martínez,Ana M, Cardoso-Martínez,Faviola, de la Rosa,José, Cueto,Mercedes, Díaz-Marrero,Ana, Darias,José, Becerril-Espinosa,Amayaly, Plata-Rosas,Luis J, Soria-Mercado,Irma E
Lenguaje:	English
Publicado:	Universidad de Valparaíso. Facultad de Ciencias del Mar 2016
Materias:	Marine actinobateria antibacterial activity cytotoxic activity Gulf of California
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572016000100015
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spelling	oai:scielo:S0718-195720160001000152016-06-24Compounds isolated from Salinispora arenicola of the Gulf of California, MéxicoÍñiguez-Martínez,Ana MCardoso-Martínez,Faviolade la Rosa,JoséCueto,MercedesDíaz-Marrero,AnaDarias,JoséBecerril-Espinosa,AmayalyPlata-Rosas,Luis JSoria-Mercado,Irma E Marine actinobateria antibacterial activity cytotoxic activity Gulf of California The marine actinobacterium AMS370, identified as Salinispora arenicola by 16S rRNA amplified gene comparison, was isolated from sediments of the Gulf of California, Mexico. From its semi-polar extract, 8 known compounds were isolated: 4-Hydroxy-phenyl acetic acid (1), 5-Methyl-2-methylene-2,3-dihydro-1H-pyrimidin-4-one (2), 1H-Pyrimidine-2,4-dione (3), 3-amino-5-hydroxy-benzoic acid (4), 2-(4-Amino-imidazol-[4,5-d]pyridazin-1-yl)-5-hydroxymethyl-4-methyl-tetrahydro-furan-3-ol (5), 3-(4-Hydroxy-phenyl)-acrylic acid methyl ester (6), 3-Benzyl-6-isobutyl-piperazine-2,5-dione (7) and 5,8-epidioxy-(22E,24R)-ergosta-6,22-dien-3-ol (Ergosterol peroxide) (8). The chemical identification was performed by comparison of their NMR spectra against the NMR spectra of the original compounds. This is the first time that compound 4 is reported as a natural product obtained from the Salinispora genus. The crude extract and all the fractions obtained were tested for antibiotic activity against Bacillus cereus, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus, Salmonella sp. and antifungic activity against Candida albicans. Also, breast cancer (MCF-7), cervical cancer (HeLa) and colorectal cancer cell lines (HCT-116) were tested to determine their cytotoxic activity. Only the semi-polar crude extract and its fractions 5.1 and 5.2 were active against Klebsiella pneumoniae and Staphylococcus aureus.info:eu-repo/semantics/openAccessUniversidad de Valparaíso. Facultad de Ciencias del MarRevista de biología marina y oceanografía v.51 n.1 20162016-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572016000100015en10.4067/S0718-19572016000100015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Marine actinobateria antibacterial activity cytotoxic activity Gulf of California
spellingShingle	Marine actinobateria antibacterial activity cytotoxic activity Gulf of California Íñiguez-Martínez,Ana M Cardoso-Martínez,Faviola de la Rosa,José Cueto,Mercedes Díaz-Marrero,Ana Darias,José Becerril-Espinosa,Amayaly Plata-Rosas,Luis J Soria-Mercado,Irma E Compounds isolated from Salinispora arenicola of the Gulf of California, México
description	The marine actinobacterium AMS370, identified as Salinispora arenicola by 16S rRNA amplified gene comparison, was isolated from sediments of the Gulf of California, Mexico. From its semi-polar extract, 8 known compounds were isolated: 4-Hydroxy-phenyl acetic acid (1), 5-Methyl-2-methylene-2,3-dihydro-1H-pyrimidin-4-one (2), 1H-Pyrimidine-2,4-dione (3), 3-amino-5-hydroxy-benzoic acid (4), 2-(4-Amino-imidazol-[4,5-d]pyridazin-1-yl)-5-hydroxymethyl-4-methyl-tetrahydro-furan-3-ol (5), 3-(4-Hydroxy-phenyl)-acrylic acid methyl ester (6), 3-Benzyl-6-isobutyl-piperazine-2,5-dione (7) and 5,8-epidioxy-(22E,24R)-ergosta-6,22-dien-3-ol (Ergosterol peroxide) (8). The chemical identification was performed by comparison of their NMR spectra against the NMR spectra of the original compounds. This is the first time that compound 4 is reported as a natural product obtained from the Salinispora genus. The crude extract and all the fractions obtained were tested for antibiotic activity against Bacillus cereus, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus, Salmonella sp. and antifungic activity against Candida albicans. Also, breast cancer (MCF-7), cervical cancer (HeLa) and colorectal cancer cell lines (HCT-116) were tested to determine their cytotoxic activity. Only the semi-polar crude extract and its fractions 5.1 and 5.2 were active against Klebsiella pneumoniae and Staphylococcus aureus.
author	Íñiguez-Martínez,Ana M Cardoso-Martínez,Faviola de la Rosa,José Cueto,Mercedes Díaz-Marrero,Ana Darias,José Becerril-Espinosa,Amayaly Plata-Rosas,Luis J Soria-Mercado,Irma E
author_facet	Íñiguez-Martínez,Ana M Cardoso-Martínez,Faviola de la Rosa,José Cueto,Mercedes Díaz-Marrero,Ana Darias,José Becerril-Espinosa,Amayaly Plata-Rosas,Luis J Soria-Mercado,Irma E
author_sort	Íñiguez-Martínez,Ana M
title	Compounds isolated from Salinispora arenicola of the Gulf of California, México
title_short	Compounds isolated from Salinispora arenicola of the Gulf of California, México
title_full	Compounds isolated from Salinispora arenicola of the Gulf of California, México
title_fullStr	Compounds isolated from Salinispora arenicola of the Gulf of California, México
title_full_unstemmed	Compounds isolated from Salinispora arenicola of the Gulf of California, México
title_sort	compounds isolated from salinispora arenicola of the gulf of california, méxico
publisher	Universidad de Valparaíso. Facultad de Ciencias del Mar
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572016000100015
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Compounds isolated from Salinispora arenicola of the Gulf of California, México

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