Evaluation of antimycobacterial activity from marine and freshwater microalgae

Abstract. Tuberculosis is considered one of the most important epidemiological diseases worldwide. The current treatment for tuberculosis is a combination of antituberculosis drugs for at least 9 months. Nowadays, the search for new pharmacological agents for the treatment of tuberculosis is an urge...

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Autores principales:	Ruiz-Güereca,Duahmet A., Licea-Navarro,Alexei F., Sánchez-Saavedra,M. del Pilar
Lenguaje:	English
Publicado:	Universidad de Valparaíso. Facultad de Ciencias del Mar 2019
Materias:	Tuberculosis microalgae crude extract tetrazolium microplate assay antimycobacterial activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572019000100082
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spelling	oai:scielo:S0718-195720190001000822019-07-31Evaluation of antimycobacterial activity from marine and freshwater microalgaeRuiz-Güereca,Duahmet A.Licea-Navarro,Alexei F.Sánchez-Saavedra,M. del Pilar Tuberculosis microalgae crude extract tetrazolium microplate assay antimycobacterial activity Abstract. Tuberculosis is considered one of the most important epidemiological diseases worldwide. The current treatment for tuberculosis is a combination of antituberculosis drugs for at least 9 months. Nowadays, the search for new pharmacological agents for the treatment of tuberculosis is an urgent endeavor. Microalgae produce a wide variety of molecules that possess biological activities of pharmaceutical interest. Therefore, the objective of this work was to evaluate the antimycobacterial activity of hexane crude extracts of 6 microalgae: Chlamydomonas mexicana, Porphyridium cruentum, Isochrysis galbana, Rhodomonas sp., Aphanocapsa marina, and Nitzschia palea. All of the hexane extracts inhibited at least 90% of the growth of Mycobacterium tuberculosis H37Rv at a concentration of 100 μg ml-1. The hexane crude extract of I. galbana had the highest antimycobacterial activity displaying a percentage inhibition that was equal to that of the antituberculosis drug isoniazid and having a minimum inhibitory concentration of 50 μg ml-1. These findings demonstrate that microalgae are an excellent source for the search of novel antimycobacterial compounds.info:eu-repo/semantics/openAccessUniversidad de Valparaíso. Facultad de Ciencias del MarRevista de biología marina y oceanografía v.54 n.1 20192019-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572019000100082en10.22370/rbmo.2019.54.1.1544
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Tuberculosis microalgae crude extract tetrazolium microplate assay antimycobacterial activity
spellingShingle	Tuberculosis microalgae crude extract tetrazolium microplate assay antimycobacterial activity Ruiz-Güereca,Duahmet A. Licea-Navarro,Alexei F. Sánchez-Saavedra,M. del Pilar Evaluation of antimycobacterial activity from marine and freshwater microalgae
description	Abstract. Tuberculosis is considered one of the most important epidemiological diseases worldwide. The current treatment for tuberculosis is a combination of antituberculosis drugs for at least 9 months. Nowadays, the search for new pharmacological agents for the treatment of tuberculosis is an urgent endeavor. Microalgae produce a wide variety of molecules that possess biological activities of pharmaceutical interest. Therefore, the objective of this work was to evaluate the antimycobacterial activity of hexane crude extracts of 6 microalgae: Chlamydomonas mexicana, Porphyridium cruentum, Isochrysis galbana, Rhodomonas sp., Aphanocapsa marina, and Nitzschia palea. All of the hexane extracts inhibited at least 90% of the growth of Mycobacterium tuberculosis H37Rv at a concentration of 100 μg ml-1. The hexane crude extract of I. galbana had the highest antimycobacterial activity displaying a percentage inhibition that was equal to that of the antituberculosis drug isoniazid and having a minimum inhibitory concentration of 50 μg ml-1. These findings demonstrate that microalgae are an excellent source for the search of novel antimycobacterial compounds.
author	Ruiz-Güereca,Duahmet A. Licea-Navarro,Alexei F. Sánchez-Saavedra,M. del Pilar
author_facet	Ruiz-Güereca,Duahmet A. Licea-Navarro,Alexei F. Sánchez-Saavedra,M. del Pilar
author_sort	Ruiz-Güereca,Duahmet A.
title	Evaluation of antimycobacterial activity from marine and freshwater microalgae
title_short	Evaluation of antimycobacterial activity from marine and freshwater microalgae
title_full	Evaluation of antimycobacterial activity from marine and freshwater microalgae
title_fullStr	Evaluation of antimycobacterial activity from marine and freshwater microalgae
title_full_unstemmed	Evaluation of antimycobacterial activity from marine and freshwater microalgae
title_sort	evaluation of antimycobacterial activity from marine and freshwater microalgae
publisher	Universidad de Valparaíso. Facultad de Ciencias del Mar
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572019000100082
work_keys_str_mv	AT ruizguerecaduahmeta evaluationofantimycobacterialactivityfrommarineandfreshwatermicroalgae AT liceanavarroalexeif evaluationofantimycobacterialactivityfrommarineandfreshwatermicroalgae AT sanchezsaavedramdelpilar evaluationofantimycobacterialactivityfrommarineandfreshwatermicroalgae
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Evaluation of antimycobacterial activity from marine and freshwater microalgae

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