Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents

Abstract:Macrocystis pyrifera is a giant brown seaweed with high nutritional content, used as a dietary supplement in some farm animals. It contains fucoidan which has a pharmacological effect on lipids and glucose metabolism. Some brown seaweeds can bioaccumulate toxic elements in their cell wall,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tapia-Martínez,Jorge, Cano-Europa,Edgar, Casas-Valdez,Margarita, Blas-Valdivia,Vanessa, Franco-Colin,Margarita
Lenguaje:	English
Publicado:	Universidad de Valparaíso. Facultad de Ciencias del Mar 2020
Materias:	Subchronic toxicity Macrocystis pyrifera safe intake antiobesogenic hypolipidemic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572020000200119
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0718-19572020000200119
record_format	dspace
spelling	oai:scielo:S0718-195720200002001192021-02-09Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodentsTapia-Martínez,JorgeCano-Europa,EdgarCasas-Valdez,MargaritaBlas-Valdivia,VanessaFranco-Colin,Margarita Subchronic toxicity Macrocystis pyrifera safe intake antiobesogenic hypolipidemic Abstract:Macrocystis pyrifera is a giant brown seaweed with high nutritional content, used as a dietary supplement in some farm animals. It contains fucoidan which has a pharmacological effect on lipids and glucose metabolism. Some brown seaweeds can bioaccumulate toxic elements in their cell wall, representing a problem if toxicity tests that guarantee the safety of their consumption are not done. M. pyrifera, does not present toxicological studies that guarantee its safety. This work aimed to perform the acute and subchronic toxicological evaluation of M. pyrifera in rodents as well as to determine its possible therapeutic effect. Fronds of M. pyrifera were collected in Baja California Sur, Mexico, for drying and obtaining algae flour. The acute toxicity test LD50 was performed in C57BL / 6 male mice (25 ± 3 g) for 7 days, finding an LD50 greater than 10 g kg-1. Subchronic toxicity was determined for 121 days in adult male Sprague Dawley rats (98 ± 2 g), during which the experimental animals showed no signs of toxicity, or changes in the hematological, biochemical and histopathological parameters of the organs. The reactive oxygen species, lipid peroxidation or glutathione ratio were not different from the control group. A therapeutic effect on the regulation of body weight and a hypolipidemic effect (triacylglycerides: 82.27 ± 5.55 mg dL-1, cholesterol: 98.61 ± 6.48 mg dL-1) were found. It is concluded that, under the conditions in which this study was developed, the consumption of M. pyrifera as a functional ingredient is safe.info:eu-repo/semantics/openAccessUniversidad de Valparaíso. Facultad de Ciencias del MarRevista de biología marina y oceanografía v.55 n.2 20202020-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572020000200119en10.22370/rbmo.2020.55.2.2497
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Subchronic toxicity Macrocystis pyrifera safe intake antiobesogenic hypolipidemic
spellingShingle	Subchronic toxicity Macrocystis pyrifera safe intake antiobesogenic hypolipidemic Tapia-Martínez,Jorge Cano-Europa,Edgar Casas-Valdez,Margarita Blas-Valdivia,Vanessa Franco-Colin,Margarita Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents
description	Abstract:Macrocystis pyrifera is a giant brown seaweed with high nutritional content, used as a dietary supplement in some farm animals. It contains fucoidan which has a pharmacological effect on lipids and glucose metabolism. Some brown seaweeds can bioaccumulate toxic elements in their cell wall, representing a problem if toxicity tests that guarantee the safety of their consumption are not done. M. pyrifera, does not present toxicological studies that guarantee its safety. This work aimed to perform the acute and subchronic toxicological evaluation of M. pyrifera in rodents as well as to determine its possible therapeutic effect. Fronds of M. pyrifera were collected in Baja California Sur, Mexico, for drying and obtaining algae flour. The acute toxicity test LD50 was performed in C57BL / 6 male mice (25 ± 3 g) for 7 days, finding an LD50 greater than 10 g kg-1. Subchronic toxicity was determined for 121 days in adult male Sprague Dawley rats (98 ± 2 g), during which the experimental animals showed no signs of toxicity, or changes in the hematological, biochemical and histopathological parameters of the organs. The reactive oxygen species, lipid peroxidation or glutathione ratio were not different from the control group. A therapeutic effect on the regulation of body weight and a hypolipidemic effect (triacylglycerides: 82.27 ± 5.55 mg dL-1, cholesterol: 98.61 ± 6.48 mg dL-1) were found. It is concluded that, under the conditions in which this study was developed, the consumption of M. pyrifera as a functional ingredient is safe.
author	Tapia-Martínez,Jorge Cano-Europa,Edgar Casas-Valdez,Margarita Blas-Valdivia,Vanessa Franco-Colin,Margarita
author_facet	Tapia-Martínez,Jorge Cano-Europa,Edgar Casas-Valdez,Margarita Blas-Valdivia,Vanessa Franco-Colin,Margarita
author_sort	Tapia-Martínez,Jorge
title	Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents
title_short	Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents
title_full	Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents
title_fullStr	Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents
title_full_unstemmed	Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents
title_sort	toxicological and therapeutic evaluation of the algae macrocystis pyrifera (phaeophyceae) in rodents
publisher	Universidad de Valparaíso. Facultad de Ciencias del Mar
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-19572020000200119
work_keys_str_mv	AT tapiamartinezjorge toxicologicalandtherapeuticevaluationofthealgaemacrocystispyriferaphaeophyceaeinrodents AT canoeuropaedgar toxicologicalandtherapeuticevaluationofthealgaemacrocystispyriferaphaeophyceaeinrodents AT casasvaldezmargarita toxicologicalandtherapeuticevaluationofthealgaemacrocystispyriferaphaeophyceaeinrodents AT blasvaldiviavanessa toxicologicalandtherapeuticevaluationofthealgaemacrocystispyriferaphaeophyceaeinrodents AT francocolinmargarita toxicologicalandtherapeuticevaluationofthealgaemacrocystispyriferaphaeophyceaeinrodents
_version_	1714202391738318848

Toxicological and therapeutic evaluation of the algae Macrocystis pyrifera (Phaeophyceae) in rodents

Ejemplares similares