Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions

This study evaluated the occurrence of highly or minimally leukotoxic strains of Aggregatibacter actinomycetemcomitans (Aa) from patients with Down syndrome and the distribution of the different serotype-specific genotypes of this microorganism. Sixty-seven patients with Down syndrome were subjected...

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Autores principales:	Gaetti Jardim,Elerson, Hissako Sumida,Doris, Schweitzer,Christiane Marie
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2013
Materias:	gingivitis bacteria periodontitis down syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2013000100017
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spelling	oai:scielo:S0718-381X20130001000172014-09-09Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal ConditionsGaetti Jardim,ElersonHissako Sumida,DorisSchweitzer,Christiane Marie gingivitis bacteria periodontitis down syndrome This study evaluated the occurrence of highly or minimally leukotoxic strains of Aggregatibacter actinomycetemcomitans (Aa) from patients with Down syndrome and the distribution of the different serotype-specific genotypes of this microorganism. Sixty-seven patients with Down syndrome were subjected to dental, periodontal and radiographic evaluations. Samples of subgingival biofilm were collected and plated onto TSBV agar and characteristic colonies of A. actinomycetemcomitans were identified by biochemical methods. The occurrence of this bacterium was also evaluated directly in the clinical specimens by PCR. The presence of 530 bp deletion in the promoter region was also determined by PCR in order to evaluate distribution of highly or minimally leukotoxic strains. A. actinomycetemcomitans was detected in 11.1% by culture and 22.2% by PCR from periodontally healthy subjects, 100% of the patients with Down syndrome with aggressive periodontitis, 50% and 75% of patients with chronic periodontitis by culture and PCR respectively. Only two patients with aggressive periodontitis were colonized by highly leukotoxic Aa. Serotype-specific genotypes a and c were the most prevalent. The results suggest the role of peculiar characteristics of Aa and patients with Down syndrome in the development of periodontitis and the influence of peculiar characteristics of the population in this process.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.7 n.1 20132013-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2013000100017en10.4067/S0718-381X2013000100017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	gingivitis bacteria periodontitis down syndrome
spellingShingle	gingivitis bacteria periodontitis down syndrome Gaetti Jardim,Elerson Hissako Sumida,Doris Schweitzer,Christiane Marie Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions
description	This study evaluated the occurrence of highly or minimally leukotoxic strains of Aggregatibacter actinomycetemcomitans (Aa) from patients with Down syndrome and the distribution of the different serotype-specific genotypes of this microorganism. Sixty-seven patients with Down syndrome were subjected to dental, periodontal and radiographic evaluations. Samples of subgingival biofilm were collected and plated onto TSBV agar and characteristic colonies of A. actinomycetemcomitans were identified by biochemical methods. The occurrence of this bacterium was also evaluated directly in the clinical specimens by PCR. The presence of 530 bp deletion in the promoter region was also determined by PCR in order to evaluate distribution of highly or minimally leukotoxic strains. A. actinomycetemcomitans was detected in 11.1% by culture and 22.2% by PCR from periodontally healthy subjects, 100% of the patients with Down syndrome with aggressive periodontitis, 50% and 75% of patients with chronic periodontitis by culture and PCR respectively. Only two patients with aggressive periodontitis were colonized by highly leukotoxic Aa. Serotype-specific genotypes a and c were the most prevalent. The results suggest the role of peculiar characteristics of Aa and patients with Down syndrome in the development of periodontitis and the influence of peculiar characteristics of the population in this process.
author	Gaetti Jardim,Elerson Hissako Sumida,Doris Schweitzer,Christiane Marie
author_facet	Gaetti Jardim,Elerson Hissako Sumida,Doris Schweitzer,Christiane Marie
author_sort	Gaetti Jardim,Elerson
title	Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions
title_short	Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions
title_full	Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions
title_fullStr	Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions
title_full_unstemmed	Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions
title_sort	distribution of serotype-specific genotypes of aggregatibacter actinomycetemcomitans in brazilian patients with down syndrome with different periodontal conditions
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2013000100017
work_keys_str_mv	AT gaettijardimelerson distributionofserotypespecificgenotypesofaggregatibacteractinomycetemcomitansinbrazilianpatientswithdownsyndromewithdifferentperiodontalconditions AT hissakosumidadoris distributionofserotypespecificgenotypesofaggregatibacteractinomycetemcomitansinbrazilianpatientswithdownsyndromewithdifferentperiodontalconditions AT schweitzerchristianemarie distributionofserotypespecificgenotypesofaggregatibacteractinomycetemcomitansinbrazilianpatientswithdownsyndromewithdifferentperiodontalconditions
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Distribution of Serotype-specific Genotypes of Aggregatibacter actinomycetemcomitans in Brazilian Patients with Down Syndrome with Different Periodontal Conditions

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