Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke

Molecular biological markers have been suggested to be of value in the diagnosis and prognostic evaluation of precancerous lesions. The purpose of the current study was to investigate the expression of p53 protein in normal oral mucosa, oral dysplastic lesions (DL), and oral squamous cell carcinoma...

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Autores principales:	Álvarez Martínez,Efraín, Jiménez-Gómez,Raul, Ardila Medina,Carlos Martin
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2013
Materias:	p53 immunohistochemistry oral squamous cell carcinoma reverse smoker
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2013000200004
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spelling	oai:scielo:S0718-381X20130002000042013-11-04Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse SmokeÁlvarez Martínez,EfraínJiménez-Gómez,RaulArdila Medina,Carlos Martin p53 immunohistochemistry oral squamous cell carcinoma reverse smoker Molecular biological markers have been suggested to be of value in the diagnosis and prognostic evaluation of precancerous lesions. The purpose of the current study was to investigate the expression of p53 protein in normal oral mucosa, oral dysplastic lesions (DL), and oral squamous cell carcinoma (SCC), comparing patients with the habit of reverse smoking and conventional smokers. The patients were subjected to incisional biopsy and the soft tissue specimens were routinely fixed in 10% formalin and processed in the laboratory. Immunohistochemical technique was performed using the avidin-biotin-peroxidase protocol. The 102 patients included 42 reverse smokers and 60 conventional smokers. There were 79 cases of mild, 15 of moderate, and 3 of severe epithelial dysplasia. Five microinvasive oral SCC included one male and four females. The clinical characteristics of microinvasive tumors included patches, plaques or erosions; 100% showed positive nuclear staining for p53. It was found a significant association of p53 expression and exposure of reverse smoking among microinvasive oral SCC and oral DL patients in the population studied.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.7 n.2 20132013-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2013000200004en10.4067/S0718-381X2013000200004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	p53 immunohistochemistry oral squamous cell carcinoma reverse smoker
spellingShingle	p53 immunohistochemistry oral squamous cell carcinoma reverse smoker Álvarez Martínez,Efraín Jiménez-Gómez,Raul Ardila Medina,Carlos Martin Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke
description	Molecular biological markers have been suggested to be of value in the diagnosis and prognostic evaluation of precancerous lesions. The purpose of the current study was to investigate the expression of p53 protein in normal oral mucosa, oral dysplastic lesions (DL), and oral squamous cell carcinoma (SCC), comparing patients with the habit of reverse smoking and conventional smokers. The patients were subjected to incisional biopsy and the soft tissue specimens were routinely fixed in 10% formalin and processed in the laboratory. Immunohistochemical technique was performed using the avidin-biotin-peroxidase protocol. The 102 patients included 42 reverse smokers and 60 conventional smokers. There were 79 cases of mild, 15 of moderate, and 3 of severe epithelial dysplasia. Five microinvasive oral SCC included one male and four females. The clinical characteristics of microinvasive tumors included patches, plaques or erosions; 100% showed positive nuclear staining for p53. It was found a significant association of p53 expression and exposure of reverse smoking among microinvasive oral SCC and oral DL patients in the population studied.
author	Álvarez Martínez,Efraín Jiménez-Gómez,Raul Ardila Medina,Carlos Martin
author_facet	Álvarez Martínez,Efraín Jiménez-Gómez,Raul Ardila Medina,Carlos Martin
author_sort	Álvarez Martínez,Efraín
title	Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke
title_short	Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke
title_full	Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke
title_fullStr	Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke
title_full_unstemmed	Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke
title_sort	immunoexpression of p53 in oral squamous cell carcinoma and oral dysplastic lesions in patients with the habit of reverse smoke
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2013000200004
work_keys_str_mv	AT alvarezmartinezefrain immunoexpressionofp53inoralsquamouscellcarcinomaandoraldysplasticlesionsinpatientswiththehabitofreversesmoke AT jimenezgomezraul immunoexpressionofp53inoralsquamouscellcarcinomaandoraldysplasticlesionsinpatientswiththehabitofreversesmoke AT ardilamedinacarlosmartin immunoexpressionofp53inoralsquamouscellcarcinomaandoraldysplasticlesionsinpatientswiththehabitofreversesmoke
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Immunoexpression of p53 in Oral Squamous Cell Carcinoma and Oral Dysplastic Lesions in Patients with the Habit of Reverse Smoke

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