Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor

The radiographic features of an intraosseous lesion are usually associated with the biological behavior of the tumor. In view of the fact that the growth and behavior of keratocystic odontogenic tumors (KCOT) is mainly associated with the proliferation of the cystic epithelium, the objective of the...

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Autores principales:	Schlaepfer-Sales,Caroline Brandi, Valverde,Ludmila De Faro, Dias,Rosane Borges, Pimentel,Bruna Natália Alves Da Silva, Melo,Leonardo De Araújo, Dos Santos,Jean Nunes, Sarmento,Viviane Almeida, Rocha,Clarissa Araújo Gurgel
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2015
Materias:	cell proliferation odontogenic cysts radiography
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2015000200007
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spelling	oai:scielo:S0718-381X20150002000072016-03-22Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic TumorSchlaepfer-Sales,Caroline BrandiValverde,Ludmila De FaroDias,Rosane BorgesPimentel,Bruna Natália Alves Da SilvaMelo,Leonardo De AraújoDos Santos,Jean NunesSarmento,Viviane AlmeidaRocha,Clarissa Araújo Gurgel cell proliferation odontogenic cysts radiography The radiographic features of an intraosseous lesion are usually associated with the biological behavior of the tumor. In view of the fact that the growth and behavior of keratocystic odontogenic tumors (KCOT) is mainly associated with the proliferation of the cystic epithelium, the objective of the present study was to evaluate the relationship between cell proliferation markers and radiographic features of this tumor. Thirty-seven radiographs of KCOT obtained from 30 patients were scanned and evaluated on a monitor. Sections were submitted to immunohistochemistry for Ki-67, p63, and p53 proteins on an EnVision system. Thirty-one KCOTs were observed in the posterior of the mandible, and the unilocular aspect was predominant (n= 26). Nineteen KCOTs distorted the mandibular canal and 11 displaced teeth. Satellite cysts were associated with a multilocular aspect (P= 0.016). p53 was in KCOTS with diffuse margins (p=0.049), p63 with NBCCS (p=0.049) KOT and higher KI-67 positive cells was observed in KCOTs presenting distortion of the mandibular canal (p=0.042). The distribution of Ki-67, p63, and p53 positive cells was similar between KCOTs with uni- and multilocular aspects. The results of the present study suggest that cell proliferation in KCOT contributes to the radiographic features of this tumor.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.9 n.2 20152015-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2015000200007en10.4067/S0718-381X2015000200007
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	cell proliferation odontogenic cysts radiography
spellingShingle	cell proliferation odontogenic cysts radiography Schlaepfer-Sales,Caroline Brandi Valverde,Ludmila De Faro Dias,Rosane Borges Pimentel,Bruna Natália Alves Da Silva Melo,Leonardo De Araújo Dos Santos,Jean Nunes Sarmento,Viviane Almeida Rocha,Clarissa Araújo Gurgel Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor
description	The radiographic features of an intraosseous lesion are usually associated with the biological behavior of the tumor. In view of the fact that the growth and behavior of keratocystic odontogenic tumors (KCOT) is mainly associated with the proliferation of the cystic epithelium, the objective of the present study was to evaluate the relationship between cell proliferation markers and radiographic features of this tumor. Thirty-seven radiographs of KCOT obtained from 30 patients were scanned and evaluated on a monitor. Sections were submitted to immunohistochemistry for Ki-67, p63, and p53 proteins on an EnVision system. Thirty-one KCOTs were observed in the posterior of the mandible, and the unilocular aspect was predominant (n= 26). Nineteen KCOTs distorted the mandibular canal and 11 displaced teeth. Satellite cysts were associated with a multilocular aspect (P= 0.016). p53 was in KCOTS with diffuse margins (p=0.049), p63 with NBCCS (p=0.049) KOT and higher KI-67 positive cells was observed in KCOTs presenting distortion of the mandibular canal (p=0.042). The distribution of Ki-67, p63, and p53 positive cells was similar between KCOTs with uni- and multilocular aspects. The results of the present study suggest that cell proliferation in KCOT contributes to the radiographic features of this tumor.
author	Schlaepfer-Sales,Caroline Brandi Valverde,Ludmila De Faro Dias,Rosane Borges Pimentel,Bruna Natália Alves Da Silva Melo,Leonardo De Araújo Dos Santos,Jean Nunes Sarmento,Viviane Almeida Rocha,Clarissa Araújo Gurgel
author_facet	Schlaepfer-Sales,Caroline Brandi Valverde,Ludmila De Faro Dias,Rosane Borges Pimentel,Bruna Natália Alves Da Silva Melo,Leonardo De Araújo Dos Santos,Jean Nunes Sarmento,Viviane Almeida Rocha,Clarissa Araújo Gurgel
author_sort	Schlaepfer-Sales,Caroline Brandi
title	Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor
title_short	Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor
title_full	Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor
title_fullStr	Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor
title_full_unstemmed	Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor
title_sort	association between radiographic features and cell proliferation in keratocystic odontogenic tumor
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2015000200007
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Association Between Radiographic Features and Cell Proliferation in Keratocystic Odontogenic Tumor

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