Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression

Alterations in the balance of the osteoblastic-osteoclastic activity (osteopetrosis, osteolysis) have an impact on the dental development. The over activation of the osteoclastogenesis pathway RANK/RANKL/OPG in RANKTg mice produces an acceleration of tooth eruption and root elongation, suggesting th...

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Autores principales:	Berdal,Ariane, Betancur,John Jairo, Morales,María Carolina, Pimienta,Carolina, Castañeda,Beatriz
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2015
Materias:	bone resorption root development epithelial cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2015000300003
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spelling	oai:scielo:S0718-381X20150003000032016-03-22Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expressionBerdal,ArianeBetancur,John JairoMorales,María CarolinaPimienta,CarolinaCastañeda,Beatriz bone resorption root development epithelial cells Alterations in the balance of the osteoblastic-osteoclastic activity (osteopetrosis, osteolysis) have an impact on the dental development. The over activation of the osteoclastogenesis pathway RANK/RANKL/OPG in RANKTg mice produces an acceleration of tooth eruption and root elongation, suggesting this pathway could control the speed of tooth formation. Evaluate the effect of osteoclastic hyperactivity on the root formation of molars in RANKTg mice. Histologic study both descriptive and comparative of the impact of hyper-resorption of the alveolar bone in Hertwig's epithelial root sheath (HERS) of molars in both RANKTg mice and controls. This is done through the immuno-detection of matrical, epithelial and cellular proliferation proteins with histological, histoenzymology and inmunohistochemical techniques. Osteoclastic hiperactivity in alveolar bone does not alter the root structure and integrity of molars in RANKTg mice; the acceleration in root formation does not alter the HERS integrity. An area of cellular hyper-proliferation in the apical follicular tissue of HERS was found, which could regulate root growth in response to osteoclastic activity. The overexpressed RANK produces an inhibition of amelogenin expression at 5 days of age, suggesting an indirect regulation of these cells by RANK/RANKL. Exploring other molecular factors expressed in HERS, and the related engram, would make possible the use of new therapies for the control of osseous and inflammatory pathologies during root formation.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.9 n.3 20152015-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2015000300003en10.4067/S0718-381X2015000300003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	bone resorption root development epithelial cells
spellingShingle	bone resorption root development epithelial cells Berdal,Ariane Betancur,John Jairo Morales,María Carolina Pimienta,Carolina Castañeda,Beatriz Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression
description	Alterations in the balance of the osteoblastic-osteoclastic activity (osteopetrosis, osteolysis) have an impact on the dental development. The over activation of the osteoclastogenesis pathway RANK/RANKL/OPG in RANKTg mice produces an acceleration of tooth eruption and root elongation, suggesting this pathway could control the speed of tooth formation. Evaluate the effect of osteoclastic hyperactivity on the root formation of molars in RANKTg mice. Histologic study both descriptive and comparative of the impact of hyper-resorption of the alveolar bone in Hertwig's epithelial root sheath (HERS) of molars in both RANKTg mice and controls. This is done through the immuno-detection of matrical, epithelial and cellular proliferation proteins with histological, histoenzymology and inmunohistochemical techniques. Osteoclastic hiperactivity in alveolar bone does not alter the root structure and integrity of molars in RANKTg mice; the acceleration in root formation does not alter the HERS integrity. An area of cellular hyper-proliferation in the apical follicular tissue of HERS was found, which could regulate root growth in response to osteoclastic activity. The overexpressed RANK produces an inhibition of amelogenin expression at 5 days of age, suggesting an indirect regulation of these cells by RANK/RANKL. Exploring other molecular factors expressed in HERS, and the related engram, would make possible the use of new therapies for the control of osseous and inflammatory pathologies during root formation.
author	Berdal,Ariane Betancur,John Jairo Morales,María Carolina Pimienta,Carolina Castañeda,Beatriz
author_facet	Berdal,Ariane Betancur,John Jairo Morales,María Carolina Pimienta,Carolina Castañeda,Beatriz
author_sort	Berdal,Ariane
title	Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression
title_short	Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression
title_full	Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression
title_fullStr	Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression
title_full_unstemmed	Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression
title_sort	evaluation of the impact of alveolar bone resorption on the root formation of molars in transgenic mice with rank over-expression
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2015000300003
work_keys_str_mv	AT berdalariane evaluationoftheimpactofalveolarboneresorptionontherootformationofmolarsintransgenicmicewithrankoverexpression AT betancurjohnjairo evaluationoftheimpactofalveolarboneresorptionontherootformationofmolarsintransgenicmicewithrankoverexpression AT moralesmariacarolina evaluationoftheimpactofalveolarboneresorptionontherootformationofmolarsintransgenicmicewithrankoverexpression AT pimientacarolina evaluationoftheimpactofalveolarboneresorptionontherootformationofmolarsintransgenicmicewithrankoverexpression AT castanedabeatriz evaluationoftheimpactofalveolarboneresorptionontherootformationofmolarsintransgenicmicewithrankoverexpression
_version_	1714203970807791616

Evaluation of the Impact of Alveolar Bone Resorption on the Root Formation of Molars in Transgenic Mice with RANK Over-expression

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