Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia

Oral lichen planus (OLP) is the most common noninfectious oral disease and is considered a potentially malignant disorders (OPMDs). The etiology and pathogenesis of OLP are not completely understood and the malignant transformation remains under discussion. The aim was to asses the cytological and h...

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Autores principales:	Paiva,Seani Neumann, Braga,Cláudia Cristina, Almeida-Coburn,Karla Loureiro, Bautz,Willian Grassi, de Barros,Liliana Aparecida Pimenta, da Gama-de-Souza,Letícia Nogueira
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2016
Materias:	oral epithelial dysplasia oral lichen planus potentially malignant disorders
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000100016
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spelling	oai:scielo:S0718-381X20160001000162016-05-23Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial DysplasiaPaiva,Seani NeumannBraga,Cláudia CristinaAlmeida-Coburn,Karla LoureiroBautz,Willian Grasside Barros,Liliana Aparecida Pimentada Gama-de-Souza,Letícia Nogueira oral epithelial dysplasia oral lichen planus potentially malignant disorders Oral lichen planus (OLP) is the most common noninfectious oral disease and is considered a potentially malignant disorders (OPMDs). The etiology and pathogenesis of OLP are not completely understood and the malignant transformation remains under discussion. The aim was to asses the cytological and histological features of OLP, and establish relationship between clinical and microscopic profiles. A total of 10 patients diagnosed with OLP were investigated. Slides were prepared and stained with HematoxylinEosin to identify 8 histological features and 8 cytological alterations. Finally, oral epithelial dysplasia degree was determined. Hyperplasia and loss of polarity of basal cells were detected in 90 % of cases. Anisonucleosis, nuclear pleomorphism and hyperchromasia affected 100 % of the sample. Six cases were classified as mild-grade OED, with no cases of severe-grade. Microscopic alterations were higher in women (P <0.0001) and moderate-grade OED was diagnosed only in this group (P <0.0014). The findings demonstrated that microscopic and clinical data association should be analyzed to a better understand of disease behavior. OED was absence only in one case, so the periodic follow-up of patients diagnosed with OLP is mandatory to avoid the malignant transformation.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.10 n.1 20162016-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000100016en10.4067/S0718-381X2016000100016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	oral epithelial dysplasia oral lichen planus potentially malignant disorders
spellingShingle	oral epithelial dysplasia oral lichen planus potentially malignant disorders Paiva,Seani Neumann Braga,Cláudia Cristina Almeida-Coburn,Karla Loureiro Bautz,Willian Grassi de Barros,Liliana Aparecida Pimenta da Gama-de-Souza,Letícia Nogueira Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia
description	Oral lichen planus (OLP) is the most common noninfectious oral disease and is considered a potentially malignant disorders (OPMDs). The etiology and pathogenesis of OLP are not completely understood and the malignant transformation remains under discussion. The aim was to asses the cytological and histological features of OLP, and establish relationship between clinical and microscopic profiles. A total of 10 patients diagnosed with OLP were investigated. Slides were prepared and stained with HematoxylinEosin to identify 8 histological features and 8 cytological alterations. Finally, oral epithelial dysplasia degree was determined. Hyperplasia and loss of polarity of basal cells were detected in 90 % of cases. Anisonucleosis, nuclear pleomorphism and hyperchromasia affected 100 % of the sample. Six cases were classified as mild-grade OED, with no cases of severe-grade. Microscopic alterations were higher in women (P <0.0001) and moderate-grade OED was diagnosed only in this group (P <0.0014). The findings demonstrated that microscopic and clinical data association should be analyzed to a better understand of disease behavior. OED was absence only in one case, so the periodic follow-up of patients diagnosed with OLP is mandatory to avoid the malignant transformation.
author	Paiva,Seani Neumann Braga,Cláudia Cristina Almeida-Coburn,Karla Loureiro Bautz,Willian Grassi de Barros,Liliana Aparecida Pimenta da Gama-de-Souza,Letícia Nogueira
author_facet	Paiva,Seani Neumann Braga,Cláudia Cristina Almeida-Coburn,Karla Loureiro Bautz,Willian Grassi de Barros,Liliana Aparecida Pimenta da Gama-de-Souza,Letícia Nogueira
author_sort	Paiva,Seani Neumann
title	Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia
title_short	Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia
title_full	Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia
title_fullStr	Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia
title_full_unstemmed	Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia
title_sort	oral lichen planus: clinical profile and determination of oral epithelial dysplasia
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000100016
work_keys_str_mv	AT paivaseanineumann orallichenplanusclinicalprofileanddeterminationoforalepithelialdysplasia AT bragaclaudiacristina orallichenplanusclinicalprofileanddeterminationoforalepithelialdysplasia AT almeidacoburnkarlaloureiro orallichenplanusclinicalprofileanddeterminationoforalepithelialdysplasia AT bautzwilliangrassi orallichenplanusclinicalprofileanddeterminationoforalepithelialdysplasia AT debarroslilianaaparecidapimenta orallichenplanusclinicalprofileanddeterminationoforalepithelialdysplasia AT dagamadesouzaleticianogueira orallichenplanusclinicalprofileanddeterminationoforalepithelialdysplasia
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Oral Lichen Planus: Clinical Profile and Determination of Oral Epithelial Dysplasia

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