Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma

This study aimed to assess the immunoexpression of cell proliferation markers (Ki-67 and Mcm-2) in oral tongue cancer, correlating it with patients' age and prognostic indicators. Sample was composed of 22 cases under 40 years and 22 over 50 years of age. Clinical staging and histological grade...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pereira,Joabe dos Santos, Barroso,Keila Martha Amorim, Nonaka,Cassiano Francisco Weege, Pinto,Leão Pereira, de Souza,Lélia Batista
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2016
Materias:	oral cancer squamous cell carcinoma age groups ki-67 antigen biological markers prognosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000300020
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0718-381X2016000300020
record_format	dspace
spelling	oai:scielo:S0718-381X20160003000202017-02-15Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell CarcinomaPereira,Joabe dos SantosBarroso,Keila Martha AmorimNonaka,Cassiano Francisco WeegePinto,Leão Pereirade Souza,Lélia Batista oral cancer squamous cell carcinoma age groups ki-67 antigen biological markers prognosis This study aimed to assess the immunoexpression of cell proliferation markers (Ki-67 and Mcm-2) in oral tongue cancer, correlating it with patients' age and prognostic indicators. Sample was composed of 22 cases under 40 years and 22 over 50 years of age. Clinical staging and histological grade of malignancy were obtained. Cell proliferation was evaluated through labeling indices. Statistical analysis was performed (p<0.05 for statistical significance). Most young patients were stages III/IV (n=13/65 %) and most older patients were stages I/II (n=11/61.1 %) (p>0.05). Mean Ki-67-LI in young and older patients was 42.4 % and 44.15 %, respectively (p>0.05). Mean Mcm-2-LI was higher in older (63.6 %) than in young patients (55.75 %) (p<0.05). We found that young patients presented more aggressive lesions in comparison to older patients, however Mcm-2 expression was significantly higher in older than in young patients. SCC of tongue can be more aggressive in young patients, and this may not be related to cell proliferation. Our findings for Mcm-2 LI and Ki-67 LI suggests that Mcm-2 could be a more sensitive marker for cell proliferation.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.10 n.3 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000300020en10.4067/S0718-381X2016000300020
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	oral cancer squamous cell carcinoma age groups ki-67 antigen biological markers prognosis
spellingShingle	oral cancer squamous cell carcinoma age groups ki-67 antigen biological markers prognosis Pereira,Joabe dos Santos Barroso,Keila Martha Amorim Nonaka,Cassiano Francisco Weege Pinto,Leão Pereira de Souza,Lélia Batista Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma
description	This study aimed to assess the immunoexpression of cell proliferation markers (Ki-67 and Mcm-2) in oral tongue cancer, correlating it with patients' age and prognostic indicators. Sample was composed of 22 cases under 40 years and 22 over 50 years of age. Clinical staging and histological grade of malignancy were obtained. Cell proliferation was evaluated through labeling indices. Statistical analysis was performed (p<0.05 for statistical significance). Most young patients were stages III/IV (n=13/65 %) and most older patients were stages I/II (n=11/61.1 %) (p>0.05). Mean Ki-67-LI in young and older patients was 42.4 % and 44.15 %, respectively (p>0.05). Mean Mcm-2-LI was higher in older (63.6 %) than in young patients (55.75 %) (p<0.05). We found that young patients presented more aggressive lesions in comparison to older patients, however Mcm-2 expression was significantly higher in older than in young patients. SCC of tongue can be more aggressive in young patients, and this may not be related to cell proliferation. Our findings for Mcm-2 LI and Ki-67 LI suggests that Mcm-2 could be a more sensitive marker for cell proliferation.
author	Pereira,Joabe dos Santos Barroso,Keila Martha Amorim Nonaka,Cassiano Francisco Weege Pinto,Leão Pereira de Souza,Lélia Batista
author_facet	Pereira,Joabe dos Santos Barroso,Keila Martha Amorim Nonaka,Cassiano Francisco Weege Pinto,Leão Pereira de Souza,Lélia Batista
author_sort	Pereira,Joabe dos Santos
title	Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma
title_short	Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma
title_full	Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma
title_fullStr	Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma
title_full_unstemmed	Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma
title_sort	immunoexpression of cell proliferation markers in oral squamous cell carcinoma
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000300020
work_keys_str_mv	AT pereirajoabedossantos immunoexpressionofcellproliferationmarkersinoralsquamouscellcarcinoma AT barrosokeilamarthaamorim immunoexpressionofcellproliferationmarkersinoralsquamouscellcarcinoma AT nonakacassianofranciscoweege immunoexpressionofcellproliferationmarkersinoralsquamouscellcarcinoma AT pintoleaopereira immunoexpressionofcellproliferationmarkersinoralsquamouscellcarcinoma AT desouzaleliabatista immunoexpressionofcellproliferationmarkersinoralsquamouscellcarcinoma
_version_	1714203986646532096

Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma

Ejemplares similares