Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene

ABSTRACT: Oral cancer, is part of several cancers that affect head and neck, and that according to numerous studies shows an increase of approximately 3-5 % of all cancers. In the last 10 years there has been an increased interest in saliva for its use as a diagnostic tool, due to its easy access, a...

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Autores principales:	Lizama,Catherine, Valenzuela,Oriana, Mejia,Magaly
Lenguaje:	English
Publicado:	Universidad de La Frontera. Facultad de Medicina 2018
Materias:	oral microbiota saliva oral cancer microbiolgical indicators.
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000100087
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spelling	oai:scielo:S0718-381X20180001000872018-05-03Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA GeneLizama,CatherineValenzuela,OrianaMejia,Magaly oral microbiota saliva oral cancer microbiolgical indicators. ABSTRACT: Oral cancer, is part of several cancers that affect head and neck, and that according to numerous studies shows an increase of approximately 3-5 % of all cancers. In the last 10 years there has been an increased interest in saliva for its use as a diagnostic tool, due to its easy access, and non-invasive sample collection, unlike blood samples. Studies of metagenomics to the microbiota of oral cancer patients have shown the presence of some groups in greater proportion, it is postulated that they could be used as markers especially in the saliva of these patients. In Antofagasta the number of patients with this type of cancer increases each year. However, there are no studies on the changes that affect the oral microbiota in these patients. The objective of this study is to contribute to the knowledge of the microbiota present in the saliva of patients with oral cancer in the region of Antofagasta, limiting this study exclusively to the group of cultivable anaerobic bacteria. The strains identified are related to the group of Streptococcus mitis / oralis, S. anginosus and S. gordoni, only one strain is grouped near the cluster that includes S. australis and S. parasanguinis. 36.4 % of the molecularly identified isolates, are closely related to the S. anginosus species described in the literature in oropharyngeal tumors. The same percentage is obtained for the taxa related to the cluster that includes S. mitis, proposed in other studies as a diagnostic indicator in subjects with oral squamous cell carcinoma.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.12 n.1 20182018-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000100087en10.4067/S0718-381X2018000100087
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	oral microbiota saliva oral cancer microbiolgical indicators.
spellingShingle	oral microbiota saliva oral cancer microbiolgical indicators. Lizama,Catherine Valenzuela,Oriana Mejia,Magaly Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene
description	ABSTRACT: Oral cancer, is part of several cancers that affect head and neck, and that according to numerous studies shows an increase of approximately 3-5 % of all cancers. In the last 10 years there has been an increased interest in saliva for its use as a diagnostic tool, due to its easy access, and non-invasive sample collection, unlike blood samples. Studies of metagenomics to the microbiota of oral cancer patients have shown the presence of some groups in greater proportion, it is postulated that they could be used as markers especially in the saliva of these patients. In Antofagasta the number of patients with this type of cancer increases each year. However, there are no studies on the changes that affect the oral microbiota in these patients. The objective of this study is to contribute to the knowledge of the microbiota present in the saliva of patients with oral cancer in the region of Antofagasta, limiting this study exclusively to the group of cultivable anaerobic bacteria. The strains identified are related to the group of Streptococcus mitis / oralis, S. anginosus and S. gordoni, only one strain is grouped near the cluster that includes S. australis and S. parasanguinis. 36.4 % of the molecularly identified isolates, are closely related to the S. anginosus species described in the literature in oropharyngeal tumors. The same percentage is obtained for the taxa related to the cluster that includes S. mitis, proposed in other studies as a diagnostic indicator in subjects with oral squamous cell carcinoma.
author	Lizama,Catherine Valenzuela,Oriana Mejia,Magaly
author_facet	Lizama,Catherine Valenzuela,Oriana Mejia,Magaly
author_sort	Lizama,Catherine
title	Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene
title_short	Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene
title_full	Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene
title_fullStr	Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene
title_full_unstemmed	Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene
title_sort	identification of the salivary microbiota of patients with oral cancer in antofagasta- chile by molecular diagnosis of the 16s rrna gene
publisher	Universidad de La Frontera. Facultad de Medicina
publishDate	2018
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2018000100087
work_keys_str_mv	AT lizamacatherine identificationofthesalivarymicrobiotaofpatientswithoralcancerinantofagastachilebymoleculardiagnosisofthe16srrnagene AT valenzuelaoriana identificationofthesalivarymicrobiotaofpatientswithoralcancerinantofagastachilebymoleculardiagnosisofthe16srrnagene AT mejiamagaly identificationofthesalivarymicrobiotaofpatientswithoralcancerinantofagastachilebymoleculardiagnosisofthe16srrnagene
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Identification of the Salivary Microbiota of Patients with Oral Cancer in Antofagasta- Chile by Molecular Diagnosis of the 16S rRNA Gene

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